Table 3

Changes in illness severity and outcomes over time

Cohort 1 1993–1996, n = 393

Cohort 2 1996–1999, n = 485

Cohort 3 1999–2002, N = 536


T4 (μg/dl)

7.6 ± 3.8 ‡

7.0 ± 3.4

6.5 ± 3.9 * †

SNAP

NA

11.2 ± 5.8

13.4 ± 7.6 †

Death

14%

13%

16%

Day of death (median, interquartile range)

7 (2–21)

10.5 (2–22)

3 (2–10) * †

Severe IVH

9%

9%

14% * †

Death and/or Severe IVH

18%

19%

26% * †


*p < .05, Cohort 1vs 3

‡p < .05, Cohort 1 vs 2

†p < .05, Cohort 2 vs 3

Paul et al. BMC Pediatrics 2006 6:2   doi:10.1186/1471-2431-6-2

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