Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent
1 Department of Paediatrics, Archbishop Makarios Hospital, 14 Longou Street, 2027, Strovolos Nicosia, Cyprus
2 Cyprus Institute of Biomedical Sciences (CIBS), Nicosia, Cyprus
3 Harvard School of Public Health, Department of Environmental Health, Environmental and Occupational Medicine and Epidemiology (EOME), Boston, MA, USA
4 Department of Virology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
BMC Pediatrics 2014, 14:6 doi:10.1186/1471-2431-14-6Published: 13 January 2014
Erythema infectiosum is the most common clinical manifestation of Parvovirus B19 infection although it has also been associated with rheumatologic diseases and various types of systemic vasculitides. Acute hepatitis and benign myositis however are rarely reported in association with Parvovirus B19 infection.
Here we report a 14-year old male, who developed acute hepatitis and benign myositis associated with erythema infectiosum following Parvovirus B19 infection.
Parvovirus B19 infection has rarely been associated with acute hepatitis and exceptionally rarely with benign myositis. Parvovirus B19 should be considered in the differential diagnosis of acute non-A to E hepatitis and in the case of acute benign myositis presenting with a rash especially in children.