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Open Access Case report

Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent

Maria Koliou12*, Evaggelia Karaoli1, Elpidoforos S Soteriades23, Sylvie Pavlides4, Stavros Bashiardes4 and Christina Christodoulou4

Author Affiliations

1 Department of Paediatrics, Archbishop Makarios Hospital, 14 Longou Street, 2027, Strovolos Nicosia, Cyprus

2 Cyprus Institute of Biomedical Sciences (CIBS), Nicosia, Cyprus

3 Harvard School of Public Health, Department of Environmental Health, Environmental and Occupational Medicine and Epidemiology (EOME), Boston, MA, USA

4 Department of Virology, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus

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BMC Pediatrics 2014, 14:6  doi:10.1186/1471-2431-14-6

Published: 13 January 2014



Erythema infectiosum is the most common clinical manifestation of Parvovirus B19 infection although it has also been associated with rheumatologic diseases and various types of systemic vasculitides. Acute hepatitis and benign myositis however are rarely reported in association with Parvovirus B19 infection.

Case presentation

Here we report a 14-year old male, who developed acute hepatitis and benign myositis associated with erythema infectiosum following Parvovirus B19 infection.


Parvovirus B19 infection has rarely been associated with acute hepatitis and exceptionally rarely with benign myositis. Parvovirus B19 should be considered in the differential diagnosis of acute non-A to E hepatitis and in the case of acute benign myositis presenting with a rash especially in children.

Parvovirus B 19; Erythema infectiosum; Hepatitis; Myositis; Cyprus