The volume-outcome relationship is supposed to be stronger in high risk, low volume procedures. The aim of this systematic review is to examine the available literature on the effects of hospital and surgeon volume, specialization and regionalization on the outcomes of the Norwood procedure.
A systematic literature search was performed in Medline, Embase, and the Cochrane Library. On the basis of titles and abstracts, articles of comparative studies were obtained in full-text in case of potential relevance and assessed for eligibility according to predefined inclusion criteria. All relevant data on study design, patient characteristics, hospital volume, surgeon volume and other institutional characteristics, as well as results were extracted in standardized tables. Study selection, data extraction and critical appraisal were carried out independently by two reviewers.
We included 10 studies. All but one study had an observational design. The number of analyzed patients varied from 75 to 2555. Overall, the study quality was moderate with a huge number of items with an unclear risk of bias. All studies investigating hospital volume indicated a hospital volume-outcome relationship, most of them even having significant results. The results were very heterogeneous for surgeon volume.
The volume-outcome relationship in the Norwood procedure can be supported. However, the magnitude of the volume effect is difficult to assess.
Keywords:Norwood procedures; Hypoplastic left heart syndrome; Outcome assessment (Health care); Mortality; Review
Previous systematic reviews (SR) have shown the presence of a significant volume-outcome relationship in surgery [1-6]. This relationship is supposed to be stronger in high risk, low volume procedures [7-10]. Two hypotheses exist for this relationship. On the one hand, a higher caseload and experience result in more effective skills (“practice makes perfect”). On the other hand, providers with better outcomes might receive more referrals increasing their volume (“selective referral”) [11,12].
Among the termination of pregnancy, compassionate care and heart transplantation, surgical palliation is the fourth treatment option for hypoplastic left heart syndrome (HLHS). A prevalence of 0.016 to 0.025% has been reported for hypoplastic left heart syndrome in neonates [13,14]. Infants suffering from hypoplastic left heart syndrome may undergo a three-stage reconstruction. The Norwood procedure is the first (stage 1 palliation) operation of a series of three operations. Surgical details on the surgical technique of the Norwood procedure can be found elsewhere [15,16]. After the Norwood procedure children will generally undergo the Glenn (stage 2 palliation at 3 to 6 months of age) and Fontan procedure (stage 3 palliation at 18 to 48 months of age) .
The Norwood procedure is associated with high mortality rates, varying between 10 and 35% [18-24]. It has been debated whether mortality rates differ by provider volume or specialization [25-28]. The introduction of minimal volume standards or other interventions leading to centralized care might be of high interest for decision-makers.
Individual studies investigating quality differences between pediatric cardiac surgical centers are known to be often underpowered . To the best of our knowledge, no SR on the volume-outcome relationship in the Norwood procedure exists. The aim of this systematic review is to examine the available literature on the effects of hospital and surgeon volume, specialization and regionalization on the outcomes of the Norwood procedure.
We performed a systematic literature search to identify all relevant publications on the relationship between provider volume or specialization and clinical outcomes. Medline (via PubMed), Embase (via Embase) and all databases of the Cochrane library were searched from inception to March 2013 (see Additional file 1 for search strategies). Reference lists of relevant articles were inspected to identify additional articles that could have been missed by our search strategy. No language restrictions were applied.
To be considered in this systematic review the following inclusion criteria were applied to each publication: the subject of the study was the Norwood procedure; the study had a comparative design; patient outcomes (e.g. mortality, morbidity) were studied; volume (if applicable) was defined as a distinct number (e.g. continuous variable) or a cut-off value, or specialized hospitals/units were analyzed; the study did not describe a single hospital or surgeon. All titles and abstracts were screened independently by two members of the research team and the full texts of potentially eligible articles were then obtained and further assessed for eligibility according to the review inclusion criteria. Any disagreements were resolved by discussion.
Data were extracted by one reviewer into structured summary tables and checked for accuracy by a second reviewer. Any disagreements were resolved through discussion until consensus was reached. For each publication, we extracted data on patient characteristics; setting; data source(s); study design and methodology; model adjustments; independent variable in terms of provider volume, specification or regionalization; and results.
The methodological quality of the eligible studies was assessed independently by two reviewers. Any disagreements were resolved by discussion. We modified a tool which is based on the Newcastle-Ottawa-Scale  that was recently used in a Cochrane review investigating the volume-outcome relationship in colorectal cancer . As many of the identified studies were expected to be registry-based, we made some minor changes to the tool. We believe that the last two questions dealing with incomplete data and missing data cannot be applied to registry-based studies. For example, registries might only incorporate data on cases with complete data. Under these circumstances a question on incomplete or missing data would be pointless. Therefore, we replaced these two questions for all registry-based studies and evaluated the “quality of registry data” and the “selection of patients” instead. Both questions were previously used for a similar question related to the volume-outcome relationship in registry-based studies . For all other studies we used the original assessment tool of the Cochrane review by Archampong et al. . In contrast to clinical trials, all registry-based studies were assessed to have a high risk of bias in the study design item in the review. We omitted this item as it seems inappropriate to assess retrospective study designs per se to be at high risk of bias with respect to our study objective. Information in registry-based studies is obtained prospectively. There is no obvious reason why registry-based studies should be at high risk of bias due to their design. Our modified assessment tool can be found in the Additional file 2.
Because the identified studies were expected to be clinically and methodologically diverse (for example, different volume definitions), we decided a priori not to statistically combine results.
Study selection and characteristics
The search strategy generated 992 hits, of which 10 studies [33,23,42] (11 publications) met our inclusion criteria (see Figure 1). Additional file 3 lists the excluded studies, along with the reasons for exclusion.
Figure 1. Flow chart.
One study was described in two publications [37,38]. All but one study  had an observational design. Eight studies were based on registry data [33,42,40,38,23], whereas two were based on clinical trial data [39,41]. We included two studies that included a subgroup analysis for the Norwood procedure [34,23]. All studies were performed in the US, one study additionally included patients from Canada . The number of analyzed patients varied from 75 to 2555. The observation periods differed widely across studies, as well (1 to 19 years). The characteristics of the studies can be found in Table 1.
Table 1. Study characteristics
Ten studies investigated the effect of hospital volume [33,42,39,38,41,23]. In four of these studies the authors also investigated surgeon volume [42,37,39,38,41]. In addition to hospital volume, two studies analyzed the data by hospital type [33,36]. Most studies employed regression models for analysis. The results of the studies are shown in Table 2.
Table 2. Study results
Table 3 summarizes the results of the quality assessment. More than half of the items were judged to have an unclear risk of bias. Only one item in one study had a high risk of bias. Addressing incomplete data or quality of registry data was the major flaw. For this item all studies had an unclear risk of bias. Many studies had also an unclear risk of bias with respect to the representativeness of the study cohort and the comparability of the intervention and control group. All but one study had a low risk of bias with respect to the assessed outcomes.
Table 3. Study quality
Berry et al.  found non-teaching hospitals to have a significantly higher hospital mortality (OR 2.6, 95% CI 1.3 - 5.3) when compared to teaching hospitals in a multivariate analysis based on the 1997 Kids Inpatient Database (KID). According to the authors’ analyses on the 2000 dataset (not shown) resulted in the same findings.
Hirsch et al.  analyzed 60 hospitals based on the Kids Inpatient Database 2003 and found the hospital mortality to be lowest in urban teaching hospitals (24.4%). This is more than 7 and 9% points lower than for urban non-teaching and rural hospitals, respectively. For more than one in four hospitals (26.6%) the type was unknown. However, these results are based on 624 Norwood procedures, 551 (88.3%) of them were performed in urban teaching hospitals.
Checchia et al.  analyzed the Pediatric Health Information System (PHIS) from 1998 to 2001. Surgeons with more than 4 Norwood procedures were defined as high volume and compared to their colleagues. Survival was higher in high volume surgeons (69% vs. 49%). Further analyses showed also a trend for mortality (treating surgeon volume as a continuous variable) and an association between the risk-unadjusted mortality and surgeon volume. However, all results did not reach statistical significance.
The Society of Thoracic Surgeons Congenital Heart Surgery Database (STS-CHSDB) was utilized to investigate the surgeon volume during a ten-year period [37,38]. Low volume surgeons (≤5 procedures) had higher mortality rates when compared to high volume surgeons with more than 10 procedures (OR 1.47, 95% CI 1.01 – 2.15). Medium volume (6–10 procedures) surgeons had also higher mortality rates, but this finding was statistically not significant (OR 1.26, 95% CI 0.88-1.78).
Morbidity outcomes were investigated in the Pediatric Heart Network Single Ventricle Reconstruction (SVR) trial, running from May 2005 to July 2008 . Surgeon volume was classified in four categories in intervals of five procedures. Results showed no clear volume-outcome relationship for renal failure. The chance for suffering from renal failure was highest in the highest surgeon volume group. However, findings supported a surgeon volume-outcome relationship for the time to first extubation and for the length of ventilation.
Karamlou et al.  did not define volume categories but treated surgeon volume solely as a continuous variable. The results of 56 surgeons who performed 710 procedures from 1994 to 2000 revealed no statistically significant relationship between surgeon volume and mortality based on the analysis of an increase of one additional case per year (p = 0.49).
Hospital mortality was associated with hospital volume based on an analysis of the Kids Inpatient Database 1997 . Statistical significance was only reached when low volume hospitals were compared with high volume hospitals (OR 3.1, 95% CI 1.1 – 8.3). Mid-low volume hospitals had a higher chance although statistical significance was not reached (OR 2.0, 95% CI 0.7 – 5.7), whereas mid-high volume hospitals had the same chance as high volume hospitals (OR 1.0, 95% CI 0.5 – 1.8). As already stated above, according to the authors, analyses on the 2000 dataset resulted in the same findings (not shown). Hirsch et al.  analyzed the Kids Inpatient Database 2003 dataset and found a highly significant hospital volume-outcome relationship based on data from 60 hospitals (p < 0.0001). A former study supports this inverse association between hospital mortality and hospital volume . The correlation coefficients were r = -0.20 (p < 0.01) for the period 1988–1992 and even r = -0.31 (p < 0.01) for the next period (1993–1997).
The PHIS (data 1998 – 2001) was utilized to investigate the hospital volume-outcome relationship with three categories in intervals of 15 procedures . Although there was a tendency for higher survival in high volume hospitals (high vs. medium vs. low, 71% vs. 62% vs. 48%) this turned out not to be significant (p = 0.08). Further analyses showed also a relationship for mortality (treating hospital volume as a continuous variable (p = 0.02) and an association between risk-unadjusted mortality (r2 = 0.18) and hospital volume (p = 0.02). Furthermore, the survival improved by 4% (95% CI 1-7%) for every 10 additional procedures performed. The hospital volume had no significant influence on the length of stay and the time to death (analyzed as mean and median).
McHugh et al.  analyzed data on 1949 Norwood procedures in 48 hospitals from the University HealthSystem Consortium (UHC) from 1998 to 2007. The hospital volume-outcome relationship was clearly supported by the findings for hospital mortality. Both low volume hospitals (OR 2.49, 95% CI 1.51-4.07) and medium volume hospitals (OR 1.75, 95% CI 1.23-2.49) had much higher mortality rates when compared with high volume hospitals (more than 30 procedures per year).
The same data source was used by Gutgesell & Gibson  who analyzed the period from 1990 to 1999. Their descriptive analysis of 40 hospitals showed a 10% point (50% vs. 40%) higher mortality rate in low volume hospitals (less than 50 procedures through study period) when compared to high volume hospitals.
The following decade (2000–2009) was analyzed with the STS-CHSDB [37,38]. Low and medium hospital volume revealed higher OR (low OR 1.37, medium OR 1.20) when compared to high volume hospitals, but both results were statistically not significant. Instead, a twofold decrease in hospital volume (treated as continuous variable) resulted in a significant finding for higher hospital mortality (OR 1.17, 95% CI 1.01-1.35). The analysis by Welke et al.  used the same data for a five-year period (2002 to 2006) and found statistically significant effects in favor of high volume hospitals. However, volume categories were not based on Norwood procedures but on pediatric cardiac surgeries.
Karamlou et al.  analyzed clinical data of 29 hospitals from 1994 to 2000. When treating hospital volume as a continuous variable an increase of one additional case per year showed no statistically significant effect on the mortality rate (p = 0.38).
The Pediatric Heart Network SVR trial showed inconclusive findings with respect to the hospital volume-outcome relationship . On the one hand, low volume hospitals had a higher chance for patients suffering from sepsis or renal failure. On the other hand, medium and high volume hospitals had a lower chance when compared to very high volume hospitals. The result for renal failure only proved to be statistically significant for high volume hospitals vs. very high volume hospitals (OR 0.32, 95% CI 0.11-0.91). Linear regression models also showed inconsistent findings for the time to first extubation, the length of ventilation and the length of stay.
This article reviewed the existing literature on the volume-outcome relationship for the Norwood procedure, including specialization and regionalization. In general, these data demonstrate the presence of a volume-outcome relationship for the Norwood procedure. However, the magnitude of the volume effect is difficult to assess. It should also be kept in mind that volume is a proxy for quality and cannot fully explain differences between centers. Among other factors such as ownership, teaching status, location, size of the hospital, in particular center-specific effects might be able to explain more differences between centers [23,43,44]. The specialization and regionalization were studied less intensively. However, the results should be interpreted with caution for reasons outlined below.
The influence of the hospital type was analyzed in two studies using the Kids Inpatient Database datasets 1997 and 2003. Both studies tend to support the hypothesis of better outcomes in teaching hospitals. The definition of teaching hospitals changed from 1997 to 2000. In the data of 2001, 20.1% of the hospitals were designated as teaching hospitals, as compared to 14.3% under the definition of 1997 . Furthermore, new US states were added to the Kids Inpatient Database longitudinally, resulting in a higher percentage of US population covered in 2003 than in 1997. The impact of these differences on the findings is hard to assess. Nevertheless, the Kids Inpatient Database is known to be representative for the US , and thus, the study results show a tendency towards lower mortality rates in teaching hospitals, although it has to be acknowledged that the majority of Norwood procedures are performed in teaching hospitals.
All studies indicated a hospital volume-outcome relationship, most of them even having significant results. These data are meaningful, but each study has limitations. The single best study was done by Berry et al.  using the Kids Inpatient Database. They found a strong hospital volume-outcome relationship and their analysis was adjusted for a number of relevant risk factors.
Surgeon volume was much less studied. Results are very heterogeneous. Only one study reported a significant result supporting the surgeon volume-outcome relationship for mortality when comparing the highest volume category with the lowest volume category [37,38]. The underlying STS-CHSDB is widely used for analyses in cardiac surgery . We were not able to fully assess the quality of the database due to a lack of information concerning the validity and completeness. However, we are aware that the quality of the data source was described elsewhere [46-48] and found to be satisfactory.
It is important to notice that the study by Tabbutt et al. is a clinical trial with inconsistent findings across volume categories. However, the findings on the time to first extubation and the length of ventilation are in congruence with our hypothesis. Although the fourth study failed marginally to reach statistical significance for mortality, the absolute risk reduction (ARR) of 20% points is highly relevant . Anyhow, this finding is difficult to interpret. On the one hand, the PHIS is a highly selective sample of more than 40 hospitals (29 hospitals at the time of writing of the study) throughout the US . On the other hand, it includes the largest children’s hospitals in the US. Given that these hospitals are highly specialized, we would have expected a lower absolute risk reduction.
Hospital or surgeon volume
This raises the question of whether surgeon volume might be more important than hospital volume. Multivariate models were applied in only two studies, one of them showing overall inconsistent findings with respect to our review question . The second study found a statistically significant effect for surgeon volume, when adjusted for hospital volume, but not for hospital volume, when adjusted for surgeon volume [37,38].
Strengths and weaknesses of the included studies
A number of issues that might have biased the study results should be kept in mind. First of all, taking volume as an outcome measure could be confusing as the number of performed procedures may classify the same hospital as low volume or high volume depending on the geographical area. This can make findings across studies difficult to compare.
Furthermore, surgeon and hospital volume were defined in several ways in our included studies. However, it has been shown that conclusions of hospital volume-outcome analyses are similar regardless of how hospital volume was defined . There are no obvious reasons why this should differ with respect to surgeon volume. In addition, there is no specific ICD-9 or other procedure code that indicates a Norwood procedure, and therefore case definitions varied by study. However, it should be noted that the STS Congenital Heart surgery database does not rely on ICD-9 nor on other procedure codes. It contains very detailed data collection forms so that it can be concluded that the misclassification of the Norwood procedure is put to a limit compared with ICD-9 codes. Two studies used data from the STS-CHSDB [23,37].
It has been questioned whether administrative data is as good as clinical data to explore the volume-outcome relationship . This is also why we assessed the quality of registry data. Nine out of eleven studies in our review were registry-based. The first clinical study had inconsistent findings , while the second used inappropriate statistics . So, we are not able to judge whether this might have influenced our results.
Limitations of the review
We acknowledge that our work has some limitations. First, we did not search for grey literature. This might have yielded additional information for other countries than the US, in particular. However, the Norwood procedure is rare due to their low incidence. Thus, meaningful analyses can be most expected from populous countries like the US. Nationwide samples from small countries would take much time to obtain a sufficient number of Norwood procedures for analysis. Changes in clinical practice would be likely to hamper the reliability of results. The low procedural volume is also reflected by the fact that even recently published studies are often based on much older data. In an outstanding case, the paper by Karamlou et al.  was published in 2010, being based on data from 1994 to 2000. The evidence presented in this systematic review is up-to-date, but our findings might not reflect the current clinical practice due to the time lag bias. Although this is a known issue in systematic reviews, the time lag bias is much more prominent in our systematic review. Furthermore, we can also not preclude the risk of overlapping databases. For instance, neonates included in the PHIS might also be included in the Kids Inpatient Database, introducing double counting of cases in our analysis (this does not affect our results for specialty centers and the hospital type).
We did not use a validated tool to appraise study quality but developed our own tool based on a previous Cochrane review, as there is no tool that can be considered the ‘gold standard’ for this kind of question. Assessing the quality of registry data was always assessed to have an unclear risk of bias due to limited information in the articles. We still believe this item to be of high relevance. As we described above, we found appropriate information in other sources than the included articles. It would require much effort to search for this information for each database. Information for older data sets might not even be available anymore. Thus, we believe it is the authors’ responsibility to provide appropriate information. However, it is not our intention to blame the authors for omitting this, as no reporting standard exists for registry-based studies.
In conclusion, this systematic review supports the presence of a volume-outcome relationship in the Norwood procedure. However, the magnitude of the volume effect is difficult to assess. There are significant clinical effects with respect to mortality. The question whether hospital volume or surgeon volume is a better predictor for outcomes needs more investigation. A concentration of Norwood procedures could lead to a decrease in mortality, although there is no evidence for a specific volume cut-off. Since volume is nothing more than a proxy for quality of care, additional criteria should be taken into consideration in planning concentration initiatives.
The study did not involve any human subjects, human material, or human data.
There is no conflict of interest to disclose.
DP conceptualized and designed the study, searched for literature, extracted and analyzed data, drafted the initial manuscript, and approved the final manuscript as submitted. TM searched for literature, extracted data and analyzed data, and approved the final manuscript as submitted. BA analyzed and interpreted data, critically reviewed the manuscript, and approved the final manuscript as submitted. All authors read and approved the final manuscript.
We thank Ms Sunya-Lee Antoine for language editing.
There was no funding for the research or publication of this article.
Financial disclosure statement
The authors have no financial relationships relevant to this article.
Gooiker GA, Van Gijn W, Post PN, Van De Velde CJH, Tollenaar RAEM, Wouters MWJM: A systematic review and meta-analysis of the volume-outcome relationship in the surgical treatment of breast cancer: are breast cancer patients better of with a high volume provider?
Goossens-Laan CA, Gooiker GA, Van Gijn W, Post PN, Bosch JLHR, Kil PJM, Wouters MWJM: A systematic review and meta-analysis of the relationship between hospital/surgeon volume and outcome for radical cystectomy: an update for the ongoing debate.
van Heek NT, Kuhlmann KF, Scholten RJ, de Castro SM, Busch OR, van Gulik TM, Obertop H, Gouma DJ: Hospital volume and mortality after pancreatic resection: a systematic review and an evaluation of intervention in the Netherlands.
Ann Surg 2005, 242(6):781-788.
Ann Surg 2006, 243(3):411-417.
JAMA 2003, 290(20):2703-2708.
N Engl J Med 2002, 346(15):1128-1137.
J Am Coll Surg 2013, 216(5):1015-1025.
Neth Heart J 2011, 19(9):369-372.
Multimedia Manual of Cardio-Thoracic Surgery 2007., 2007(1217)
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2013, 16(1):52-58.
Ohye RG, Sleeper LA, Mahony L, Newburger JW, Pearson GD, Lu M, Goldberg CS, Tabbutt S, Frommelt PC, Ghanayem NS, Laussen PC, Rhodes JF, Lewis AB, Mital S, Ravishankar C, Williams IA, Dunbar-Masterson C, Atz AM, Colan S, Minich LL, Pizarro C, Kanter KR, Jaggers J, Jacobs JP, Krawczeski CD, Pike N, McCrindle BW, Virzi L, Gaynor JW: Comparison of shunt types in the Norwood procedure for single-ventricle lesions.
N Engl J Med 2010, 362(21):1980-1992.
Ann Thorac Surg 2004, 77(5):1727-1733.
Jacobs JP, O’Brien SM, Pasquali SK, Jacobs ML, Lacour-Gayet FG, Tchervenkov CI, Austin EH 3rd, Pizarro C, Pourmoghadam KK, Scholl FG, Welke KF, Mavroudis C: Variation in outcomes for benchmark operations: an analysis of the society of thoracic surgeons congenital heart surgery database.
Ann Thorac Surg 2011, 92(6):2184-2191.
discussion 2191–2182. doi:10.1016/j.athoracsur.2011.06.008
Karamichalis JM, del Nido PJ, Thiagarajan RR, Jenkins KJ, Liu H, Gauvreau K, Pigula FA, Fynn-Thompson FE, Emani SM, Mayer JE Jr, Bacha EA: Early postoperative severity of illness predicts outcomes after the stage I Norwood procedure.
Ann Thorac Surg 2011, 92(2):660-665.
Ann Thorac Surg 2003, 76(4):1084-1088.
Tabbutt S, Dominguez TE, Ravishankar C, Marino BS, Gruber PJ, Wernovsky G, Gaynor JW, Nicolson SC, Spray TL: Outcomes after the stage I reconstruction comparing the right ventricular to pulmonary artery conduit with the modified Blalock Taussig shunt.
Ann Thorac Surg 2005, 80(5):1582-1590.
discussion 1590–1581. doi:10.1016/j.athoracsur.2005.04.046
J Thorac Cardiovasc Surg 2009, 137(5):1133-1140.
EACTS Congenital Databasehttp://www.eactscongenitaldb.org/db/public-reports.py?fnc=r42&dbname=database webcite. Accessed 08/10/2013
Pediatr Cardiol 2012, 33(2):229-238.
Pediatrics 2002, 110(4):849-850.
Ann Thorac Surg 2010, 89(1):139-144.
discussion 145–136. doi:10.1016/j.athoracsur.2009.08.058
The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses.
http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp webcite. Accessed 24.12.2012
Cochrane Database Syst Rev 2012, 3:CD005391.
Institute for Quality and Efficiency in Health Care (IQWiG): Zusammenhang zwischen der Menge der erbrachten Leistungen und der Ergebnisqualität für die Indikation “Elektiver Eingriff Bauchaortenaneurysma”. Cologne: IQWiG; 2006.
Pediatrics 2006, 117(4):1307-1313.
Pediatr Cardiol 2008, 29(4):713-717.
Ann Thorac Surg 2012, 93(6):1992-1997.
Pasquali SK, Jacobs JP, He X, Hornik CP, Jaquiss RDB, Jacobs ML, O’Brien SM, Peterson ED, Li JS: The complex relationship between center volume and outcome in patients undergoing the norwood operation.
Karamlou T, McCrindle BW, Blackstone EH, Cai S, Jonas RA, Bradley SM, Ashburn DA, Caldarone CA, Williams WG: Lesion-specific outcomes in neonates undergoing congenital heart surgery are related predominantly to patient and management factors rather than institution or surgeon experience: a congenital heart surgeons society study.
J Thorac Cardiovasc Surg 2010, 139(3):569-577.
Tabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, Frank DU, Lu M, Pizarro C, Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L, Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P: Risk factors for hospital morbidity and mortality after the Norwood procedure: a report from the pediatric heart network single ventricle reconstruction trial.
J Thorac Cardiovasc Surg 2012, 144(4):882-895.
J Thorac Cardiovasc Surg 2005, 129(4):754-759.
Health Econ 2014.
N Engl J Med 2012, 367(1):3-6.
Jacobs JP, Edwards FH, Shahian DM, Haan CK, Puskas JD, Morales DL, Gammie JS, Sanchez JA, Brennan JM, O’Brien SM, Dokholyan RS, Hammill BG, Curtis LH, Peterson ED, Badhwar V, George KM, Mayer JE Jr, Chitwood WR Jr, Murray GF, Grover FL: Successful linking of the society of thoracic surgeons adult cardiac surgery database to centers for medicare and medicaid services medicare data.
Ann Thorac Surg 2010, 90(4):1150-1156.
discussion 1156–1157. doi:10.1016/j.athoracsur.2010.05.042
Johnson JN, Jaggers J, Li S, O’Brien SM, Li JS, Jacobs JP, Jacobs ML, Welke KF, Peterson ED, Pasquali SK: Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome.
J Thorac Cardiovasc Surg 2010, 139(5):1205-1210.
Cardiol Young 2008, 18(Suppl 2):177-187.
Narus SP, Srivastava R, Gouripeddi R, Livne OE, Mo P, Bickel JP, de Regt D, Hales JW, Kirkendall E, Stepanek RL, Toth J, Keren R: Federating clinical data from six pediatric hospitals: process and initial results from the PHIS + consortium.
The pre-publication history for this paper can be accessed here: