Table 3

Summary of logistic regression analyses of atopic diseases in late childhood in 586 Norwegian children according to mother’s preeclampsia status
Effects of maternal preeclampsia
Fully adjusteda) Final analysisb)
n Mild/moderate preeclampsia Severe preeclampsia Likelihood-ratio- n Mild/moderate preeclampsia Severe preeclampsia Likelihood-ratio
Outcome variable OR 95% CI OR 95% CI p OR 95% CI OR 95% CI p
FU1 variables
Allergic rhinoconjunctivitis 514 1.21 (0.70, 2.07) 2.10 (0.86, 5.11) 0.268 586 1.25 (0.79, 1.97) 2.23 (1.20, 4.17) 0.046
Atopic dermatitis 513 0.90 (0.54, 1.50) 0.97 (0.39, 2.39) 0.914 ____
Asthma 506 0.87 (0.38, 1.97) 0.72 (0.19, 2.77) 0.878 ____
FU2 variables
Allergic sensitization 329 1.49 (0.84, 2.63) 2.44 (0.93, 6.42) 0.138 ____
High level allergic sensitizationc) 329 1.64 (0.87, 3.11) 4.42 (1.58, 12.3) 0.015 347 1.60 (0.88, 2.91) 4.05 (1.62, 10.1) 0.010d)
Current asthma 388 1.11 (0.45, 2.73) 0.69 (0.15, 3.18) 0.802 ____

Abbreviations:OR Odds ratio, CI Confidence interval, FU1 first follow-up at the ages of 10.8 years (girls) and 11.8 years (boys), FU2 second follow-up at the age of 12.8 years (both genders); Likelihood-ratio-p refers to exposure only.

a)Adjusted for gender, birth weight z-score adjusted for gestational age, being firstborn, Caesarean section, maternal smoking during pregnancy, gestational age in weeks, maternal age, maternal body mass index (kg/m2) and maternal asthma;

b)After backward stepwise selection from fully adjusted model with p ≤ 0.05; all final analyses include the covariates gender and maternal asthma as default.

c)High level allergic sensitization = Sum of specific IgE > 3.9 kU/l; the 25 percentile of sensitized children.

d)Adjusted for gender, maternal smoking during pregnancy, gestational age in weeks and maternal asthma. No significant interaction effects were found in final analyses.

Byberg et al.

Byberg et al. BMC Pediatrics 2014 14:101   doi:10.1186/1471-2431-14-101

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