Table 2

Atopy, asthma and lung function in late childhood in 586 Norwegian children according to mother’s preeclampsia status
Severe preeclampsia Mild/moderate preeclampsia No preeclampsia Severe vs. no preeclampsia Mild/moderate vs. no preeclampsia Overall
Outcome variable n n n p-valuea) p-valuea) p-valueb)
FU1 variables
Allergic rhinoconjunctivitis, n (%) 54 19 (35.2) 161 36 (22.4) 371 71 (19.1) 0.018 0.822 0.015
Atopic dermatitis, n (%) 54 15 (27.8) 163 37 (22.7) 369 92 (24.9) 1.476 1.172 1.000
Asthma, n (%) 53 9 (17.0) 161 14 (8.7) 366 30 (8.2) 0.092 1.730 0.100
FU2 variables
Allergic sensitization, n (%) 39 15 (38.5) 112 40 (36.3) 230 72 (31.3) 0.918 0.924 0.296
High level allergic sensitization, n (%)c) 39 15 (38.5) 112 28 (25.0) 230 50 (21.7) 0.056 1.166 0.042
Current asthma, n (%) 46 6 (13.0) 123 12 (9.8) 279 19 (6.8) 0.454 0.630 0.126
FEV1%, mean, 95% CI 45 89.7 (87.0, 92.5) 126 91.0 (89.0, 93.0) 272 91.1 (90.0, 92.2) 1.000 1.000 0.682
FVC%, mean, 95% CI 45 99.2 (95.5, 102.8) 126 100.0 (97.7, 102.3) 272 101.1 (99.8, 102.4) 0.965 1.000 0.489
FEV1/FVC, mean, 95% CI 45 84.6 (82.7, 86.5) 126 85.3 (83.9, 86.6) 272 84.9 (84.1, 85.7) 1.000 1.000 0.482
FEF25–75%, mean, 95% CI 45 84.9 (79.4, 90.3) 126 89.6 (85.9, 93.4) 272 87.4 (85.1, 89.6) 1.000 0.827 0.317
FEF25–75/FVC, mean, 95% CI 45 54.5 (50.0, 59.0) 126 57.3 (54.7, 59.9) 272 55.7 (54.1, 57.4) 1.000 0.906 0.429

Abbreviations:FU1 first follow-up at the ages of 10.8 years (girls) and 11.8 years (boys), FU2 second follow-up at the age of 12.8 years (both genders), FEV1% forced expiratory volume in first second predicted, CI Confidence interval, FVC% forced vital capacity predicted, FEF25–75% forced expiratory flow between 25% and 75% of the forced vital capacity, predicted.

a)Pearson’s exact chi-square test (dichotomous variable) and one way analysis of variance (continuous variable) with Bonferroni corrections;

b)Cochran-Armitage test for dichotomous outcomes and one way analysis of variance for continuous outcomes;

c)Sum of specific IgE > 3.9 kU/l.

Byberg et al.

Byberg et al. BMC Pediatrics 2014 14:101   doi:10.1186/1471-2431-14-101

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