Table 7

Prediction of moderate-severe HIE presenting in the first 72 hours after birth
Encephalopathy assessment n moderate-severe HIE n (%) Sensitivity (95%CI) Specificity (95%CI) LR + (95%CI) LR - (95%CI) LR Test (Odds ratio) (95%CI)
aEEG abnormal age 6 hours Yes 36 36 (100) 75% 100% 19.4 a 0.27 a 73 a
No 24 12 (50) (60 – 86) (74 – 100) (1.3 – 294.9) (0.16 – 0.43) (4 – 1325)
Moderate-severe encephalopathy age 3 – 5 hours Yes 42 42 (100) 88% 100% 23 a 0.1 a 163.5 a
No 18 6 (33) (75 – 95) (74 – 100) (1.5 – 342.4) (0.1 – 0.3) (8.6 – 3106.8)
Thompson score ≥ 7 age 3 – 5 hours Yes 44 43 (98) 90% 92% 7.7 a 0.1 a 60.6 a
No 16 5 (31) (77 – 97) (62 – 100) (1.7 – 34.8) (0.1 – 0.3) (8.9 – 413.1)
aEEG abnormal age 3 hours and/or 6 hours Yes 40 39 (98) 81% 50% 1.6 a 0.4 a 4.2 a
No 10 9 (90) (67 – 91) (1 – 99) (0.5 – 5) (0.1 – 1.4) (0.4 – 44.5)

aEEG: amplitude integrated electro-encephalogram, LR: Likelihood ratio, CI: Confidence Interval, LOC: Level of consciousness.

HIE: Hypoxic ischaemic encephalopathy.

a: When zero count cells are present, LR is estimated using a substitution formula: 0.5 is added to all cell frequencies before calculation.

Horn et al.

Horn et al. BMC Pediatrics 2013 13:52   doi:10.1186/1471-2431-13-52

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