Kawasaki disease and subsequent risk of allergic diseases: a population-based matched cohort study
1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
2 Department of Clinical Pharmacy; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
3 The Department of Medical Research and Development of Pediatrics, Show Chwan Memorial Hospital in Chang Bing, Changhua, Taiwan
4 Institute of Clinical Medical Sciences, National Yang Ming University, Taipei, Taiwan
5 Department of Pediatrics, Po-Jen Hospital, Kaohsiung, Taiwan
6 Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan
BMC Pediatrics 2013, 13:38 doi:10.1186/1471-2431-13-38Published: 23 March 2013
The risk of allergic diseases among Kawasaki disease (KD) patients relative to the general population is not known. The aim of this study was to perform a population-based cohort study to investigate the risk of allergic diseases among children after KD in Taiwan- a country with the third highest incidence of KD in the world.
Data were obtained from the Taiwan National Health Insurance Research Database. In total, 253 patients who were 5 years of age or younger and had a first-time hospitalization with a diagnosis of KD between 1997 and 2005 were included as the study cohort and 1,012 non-KD patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression model was used to adjust for confounding and to compare the 6-year allergic-free survival rate between these two cohorts.
The incidence rate of allergic diseases (184.66 per 1000 person-year) was significantly higher in the KD cohort than in the control cohort (124.99 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios of asthma and allergic rhinitis were 1.51 (95% confidence interval = 1.17-1.95) and 1.30 (95% confidence interval = 1.04-1.62), respectively.
We conclude that KD patients were at an increased risk for allergic diseases compared with the comparison cohort.