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Open Access Research article

Kawasaki disease and subsequent risk of allergic diseases: a population-based matched cohort study

Ho-Chang Kuo1, Wei-Chiao Chang2, Kuender D Yang34, Hong-Ren Yu1, Chih-Lu Wang5, Shu-Chen Ho6 and Chun-Yuh Yang6*

Author Affiliations

1 Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

2 Department of Clinical Pharmacy; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei, Taiwan

3 The Department of Medical Research and Development of Pediatrics, Show Chwan Memorial Hospital in Chang Bing, Changhua, Taiwan

4 Institute of Clinical Medical Sciences, National Yang Ming University, Taipei, Taiwan

5 Department of Pediatrics, Po-Jen Hospital, Kaohsiung, Taiwan

6 Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

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BMC Pediatrics 2013, 13:38  doi:10.1186/1471-2431-13-38

Published: 23 March 2013

Abstract

Background

The risk of allergic diseases among Kawasaki disease (KD) patients relative to the general population is not known. The aim of this study was to perform a population-based cohort study to investigate the risk of allergic diseases among children after KD in Taiwan- a country with the third highest incidence of KD in the world.

Methods

Data were obtained from the Taiwan National Health Insurance Research Database. In total, 253 patients who were 5 years of age or younger and had a first-time hospitalization with a diagnosis of KD between 1997 and 2005 were included as the study cohort and 1,012 non-KD patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression model was used to adjust for confounding and to compare the 6-year allergic-free survival rate between these two cohorts.

Results

The incidence rate of allergic diseases (184.66 per 1000 person-year) was significantly higher in the KD cohort than in the control cohort (124.99 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios of asthma and allergic rhinitis were 1.51 (95% confidence interval = 1.17-1.95) and 1.30 (95% confidence interval = 1.04-1.62), respectively.

Conclusion

We conclude that KD patients were at an increased risk for allergic diseases compared with the comparison cohort.

Keywords:
Kawasaki disease; Allergic disease; Cohort study