Table 3

Comparison of abnormal values of diagnostic markers between neoplasia and JIA patients
Diagnostic markers All patients n/N (%) Neoplasia n/N (%) JIA n/N (%) p-value (Neoplasia versus JIA) Sensitivity Specificity PPV NPV LR+ LR-
WBC count 66/128 (51.6) 33/60 (55.0) 33/68 (48.5) 0.484
Neutrophil count 27/116 (23.3) 25/55 (45.5) 2/61 (3.3) 0.000 45.5% 96.7% 92.5% 66.2% 13.8 0.6
Platelet count 98/128 (76.6) 47/60 (78.3) 51/68 (75.0) 0.682
Hb 40/128 (31.3) 34/60 (56.7) 6/68 (8.8) 0.000 56.7% 91.2% 85.0% 70.4% 6.4 0.5
LDH 84/107 (78.5) 51/58 (87.9) 33/49 (67.3) 0.017 87.9% 32.7% 60.7% 69.5% 1.3 0.4
ESR 87/105 (82.9) 33/37 (89.2) 54/68 (79.4) 0.281
CRP 86/113 (76.1) 39/52 (75.0) 47/61 (77.0) 0.828
ANA 35/81 (43.2) 3/19 (15.8) 32/62 (51.6) 0.008 15.8% 48.4% 8.5% 65.2% 0.3 1.7
IgG 38/108 (35.2) 16/51 (31.4) 22/57 (38.6) 0.545
IgM 8/108 (7.4) 4/51 (7.8) 4/57 (7.0) 1.000
IgA 26/108 (24.1) 18/51 (35.3) 8/57 (14.0) 0.013 35.3% 86.0% 69.2% 59.7% 2.5 0.8
C3 47/90 (52.2) 22/36 (61.1) 25/54 (46.3) 0.200
C4 26/89 (29.2) 17/36 (47.2) 9/53 (17.0) 0.004 47.2% 83.0% 65.3% 69.8% 2.8 0.6
Anti-EBV IgM 8/58 (13.8) 7/44 (15.9) 1/14 (7.1) 0.665
Anti-EBV IgG 41/59 (69.5) 33/44 (75.0) 8/15 (53.3) 0.192
Anti-EA EBV IgG 14/45 (31.1) 14/35 (40.0) 0/10 (0) 0.019 40.0% 100% 1.0% 32.2% - 0.6
Anti-CMV IgM 4/44 (9.1) 2/34 (5.9) 2/10 (20.0) 0.218
Anti-CMV IgG 26.43 (60.5) 24/33 (72.7) 2/10 (20.0) 0.007 72.7% 80.0% 92.3% 47.0% 3.6 0.3

Agodi et al.

Agodi et al. BMC Pediatrics 2013 13:15   doi:10.1186/1471-2431-13-15

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