Table 3

Differences between survivors without significant BPD and deceased or surviving infants with significant BPD
SWsBPD Deceased/Significant BPD p-value*
(n = 299) (n = 116)
Year of birth 0.032
- 1997–2000 38 (58.5%) 27 (41.5%)
- 2001–2005 132 (74.2%) 46 (25.8%)
- 2006–2009 129 (75.0%) 43 (25.0%)
Gestational age (w) 27.6 (26.1-29.4) 25.4 (24.4-27.0) <0.001
Birth weight (g) 850 (750–935) 680 (589–780) <0.001
IUGR 112 (38.5%) 37 (34.9%) 0.515
Multiple gestation 102 (34.1%) 48 (41.4%) 0.167
Male gender 135 (45.2%) 63 (54.3%) 0.094
Chorioamnionitis 48 (16.1%) 33 (28.4%) 0.004
Antibiotics (mother) 167 (59.6%) 78 (69.6%) 0.065
Prenatal steroids 277 (95.2%) 97 (84.3%) <0.001
Cesarean section 213 (72.0%) 53 (45.7%) <0.001
Apgar at 1 minute ≤3 29 (9.7%) 37 (32.5%) <0.001
Apgar at 5 minutes ≤6 29 (9.7%) 32 (28.3%) <0.001
Umbilical artery pH 7.26 (7.17-7.31) 7.29 (7.19-7.32) 0.165
Resuscitation <0.001
- Not performed 67 (22.4%) 6 (5.2%)
- Mask/IPPV + PEEP 121 (40.5%) 20 (17.2%)
- ET intubation 102 (34.1%) 79 (68.1%)
- ET Intubation +
chest compression +
epinephrine 9 (3.0%) 11 (9.5%)
CRIB 4 (1–6) 9 (7–13) <0.001
RDS 146 (48.8%) 92 (79.3%) <0.001
Mechanical ventilation 184 (61.5%) 116 (100%) <0.001
Sepsis 124 (41.5%) 54 (46.6%) 0.349
NEC 17 (5.7%) 13 (11.2%) 0.052
IVH 52 (17.4%) 45 (38.8%) <0.001
- Grades III/IV 11 (3.7%) 34 (29.3%) <0.001
PVLM 6 (3.1%) 4 (4.5%) 0.536
PDA 105 (35.1%) 43 (37.1%) 0.710
- Surgical closure 25 (8.4%) 6 (5.2%) 0.268
Severe arterial
hypotension 10 (3.4%) 30 (26.1%) <0.001

CRIB: clinical risk index for babies; IUGR: intrauterine growth restriction; ET: endotracheal; RDS: respiratory distress syndrome; NEC: necrotizing enterocolitis; IVH: peri-intraventricular hemorrhage; PEEP: positive end expiratory pressure; PVLM: periventricular leukomalacia; PDA: patent ductus arteriosus; SWsBPD: survival without significant BPD.

Median (IQR: 25th-75th percentile), number (%).

* Mann–Whitney U or chi-square test.

Botet et al.

Botet et al. BMC Pediatrics 2012 12:63   doi:10.1186/1471-2431-12-63

Open Data