Table 1

Rates of lymphocyte respiration, thyroid function and clinical findings in trisomy 21 children
Children No. Age (yr) Gender BMI (kg/m2) kc(μM O2min-1per 107cells) TSH (mIU/L) Free T4 (pmol/L) Clinical status
1 1.5 F 12.8 1.6 3.5 20.7 AVSD
2 5 M 16.1 2.0 1.6 14.7 celiac disease
3 17 M 28.6 1.2 4.9 9.5 normal
4 12 M 16.3 0.6 2.6 10 AVSD
5 12 F 30.8 1.2 3.8 13.2 VSD
6 9 M 17.1 0.6 2.6 NA bronchial asthma
7* 15 M 30.2 0.6 2.8 10.0 aortic stenosis, hypothyroidism
8 15 M 44.3 2.8 13.2 11.0 Moya Moya disease, hypothyroidism
9 3 F 13.8 0.4 3.7 14.2 bronchial asthma
10 2 F 15.2 0.6 5.3 13.0 obstructive sleep apnea, low vitamin D
11 3 M 14.5 0.5 2.9 15.8 ASD, PDA
12 5 M 17.5 0.9 2.6 9.9 VSD
13* 4 M 15.7 0.2 12.6 11.6 hypothyroidism
14 10 F NA 0.8 5.1 10.4 normal
15 6 M 18.7 0.4 5.1 10.5 normal
16 4 M 14.8 1.2 3.6 11.9 normal
17 9 F 16 0.7 3.9 10.7 normal
18 1.5 M 16.3 1.5 11.6 11.9 hypothyroidism
19 5 M NA 1.0 2.9 11.1 normal
20 6 M 20.7 0.3 3.9 10.4 normal
21 8 M 31.4 0.4 5.1 10.5 asthma, myelomeningocele
22 2 F 14.3 0.3 7.7 11.2 normal
23 7 F 17.8 0.3 1.3 9.3 normal
24 8 F 23.2 0.2 3.7 11.3 AVSD
25 6 M 35.1 0.2 3.6 14.1 AVSD
26 4 M 13.6 0.7 6.4 14.1 normal
mean ± SD (CV) 6.9 ± 4.4 20.6 ± 8.3 (40%) 0.82 ± 0.62 (76%) 4.8 ± 3.1 12.0 ± 2.5

AVSD, atrioventricular septal defect; VSD, ventricular septal defect; ASD, atrial septal defect; PDA, patent ductus arteriosus; CV, coefficient of variation. NA, not available.

In normal 2 to7 year-old children, the TSH values are 0.10 to 5.9 mU/L (mean = 2.2 mU/L); in normal 9 to 16 year-old children, the TSH values are 0.20 to 6.1 mU/L (mean = 2.3 mU/L).

Reference ranges for free T4 are 11.0 to 22.6 pmol/L in children 1 to 5 years of age, 11.6 to 21.5 pmol/L in children 6 to 10 years of age, and 12.0 to 20.6 pmol/L in children 11 to 19 years of age ( https://www.labcorp.com/wps/portal/provider webcite).

* On thyroxin prior to O2 consumption testing.

Aburawi and Souid

Aburawi and Souid BMC Pediatrics 2012 12:193   doi:10.1186/1471-2431-12-193

Open Data