Table 1

Risk of asthma, recurrent wheeze and bronchial hyperreactivity with various metrics of environmental tobacco smoke
2 years 7 years
Recurrent wheeze Asthma Bronchial hyperreactivity
Yes No Adjusted* OR# Yes No Adjusted OR Yes No Adjusted OR
Measures at 3rd trimester/birth Maternal smoking (self-reported) during 3rd trimester 5/23 (21.7) 18/252 (7.1) 3.5 (1.2,10.7) p=0.025 4/50 (8.0) 19/229 (8.3) 0.5 (0.1,1.6) 11/146 (7.5) 9/112 (8.0) 0.9 (0.4,2.3)
Any family member smoking (self-reported) during 3rd trimester 11/23 (47.8) 60/252 (23.8) 2.9 (1.2,7.0) p=0.015 14/50 (28.0) 58/229 (25.3) 0.9 (0.4,1.9) 38/146 (26.0) 29/112 (25.9) 1.0 (0.6,1.8)
Cord blood cotinine above 50th percentile 16/23 (69.6) 119/252 (47.2) 2.6 (1.0,6.5) p=0.045 31/50 (62.0) 106/229 (46.3) 1.7 (0.9,3.2) 74/146 (50.7) 51/112 (45.5) 1.2 (0.7,2.0)
Measures at 12 months Maternal smoking (self-reported) at 12 months 4/33 (12.1) 29/332 (8.7) 1.3 (0.4,4.1) 5/71 (7.0) 28/299 (9.4) 0.3 (0.1,1.0) 15/188 (8.0) 15/150 (10.0) 0.8 (0.4,1.7)
Any family member smoking (self-reported) at 12 months 10/33 (30.3) 66/332 (19.9) 1.7 (0.8,3.8) 15/71 (21.1) 62/299 (20.7) 0.7 (0.3,1.4) 45/188 (23.9) 27/150 (18.0) 1.5 (0.9,2.7)
Urinary cotinine:Cr above 50th percentile at 12 months 23/33 (69.7) 167/332 (50.3) 2.2 (0.99,4.7) 43/71 (60.6) 149/299 (49.8) 1.2 (0.7,2.1) 94/188 (50.0) 79/150 (52.7) 0.9 (0.6,1.3)

BOLD indicates p < 0.05 frequency of exposure at given age amongst those with (“yes”) or without (“no”) given diagnosis.

* each model adjusted for group allocation (“intervention”) and for any baseline characteristic (race gender, history of asthma, maternal education, residence city, season, child’s atopic status) with p<0.05 upon being entered in a stepwise manner.

# odds of having given respiratory condition amongst those with given ETS exposure relative to those without such ETS exposure (95% CI).

Carlsten et al.

Carlsten et al. BMC Pediatrics 2012 12:187   doi:10.1186/1471-2431-12-187

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