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Open Access Case report

Severe acquired cytomegalovirus infection in a full-term, formula-fed infant: Case Report

Alberto Berardi1*, Cecilia Rossi1, Valentina Fiorini1, Cristina Rivi2, Federica Vagnarelli3, Nicola Guaraldi4, Paola Pietrosemoli5, Tiziana Lazzarotto6 and Fabrizio Ferrari1

Author Affiliations

1 Unità Operativa di Terapia Intensiva Neonatale, Azienda Ospedaliero-Universitaria Policlinico di Modena, Italy

2 Unità Operativa di Pediatria, Ospedale Ramazzini di Carpi, Italy

3 Unità Operativa di Terapia Intensiva Neonatale, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

4 Unità operativa di Pediatria, Azienda Ospedaliero-Universitaria Policlinico di Modena, Italy

5 Struttura Complessa di Microbiologia e Virologia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Italy

6 Unità Operativa di Microbiologia, Azienda Ospedaliero-Universitaria Policlinico S. Orsola Malpighi, Università di Bologna, Italy

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BMC Pediatrics 2011, 11:52  doi:10.1186/1471-2431-11-52

Published: 6 June 2011

Abstract

Background

Cases of cytomegalovirus colitis are exceptionally reported in immuno-competent infant. The pathogenesis is uncertain but breast-feeding is considered as a main source of postnatal infection.

Case Presentation

Here we report a full-term, formula-fed infant who developed a severe cytomegalovirus anaemia and colitis when aged 2 months.

Conclusion

Even if the molecular identity between the cytomegalovirus-isolate of the infant and the maternal virus could not be demonstrated, we confirmed through laboratory investigation that cytomegalovirus infection was acquired postnatally. However, the source of cytomegalovirus infection remained unclear. Alternative modes of cytomegalovirus transmission are discussed.