Table 5

Minerals: The average levels of minerals measured in the Neurotypical group and the Arizona Autism Treatment and Arizona Autism Placebo groups (pre and post) who completed the study are reported below, along with their standard deviations.

Essential Minerals + other minerals

Neuro-typicals

(n = 44)

Treatment Group

(n = 19)

Placebo Group

(n = 20)


Pre

Post

% change

p-value

Pre

Post

% change

p-value


Calcium-WB

(mg/dL)

5.8

+/- 0.3

5.9

+/- 0.4

6.0

+/0.4

+1%

n.s.

5.8

+/- 0.3

5.6

+/- 0.5

-2%

n.s.


Calcium-RBC

(ug/g)

22.4

+/- 6

19.2

+/- 7.9

27.4

+/- 3.6

+43%

0.001

19.5

+/- 7.5

25.2

+/- 4.3

+30%

0.02


Calcium-Serum

(mg/dL)

9.60

+/- 0.2

9.65

+/- 0.4

9.51

+/- 0.3

-1%

0.07

9.59

+/- 0.4

9.53

+/- 0.3

0%

n.s.


Chromium-RBC

(ng/g)

0.80

+/- 0.4

1.02

+/- 0.50

0.81

+/- 0.6

-21%

n.s.

0.77

+/- 0.44

0.70

+/- 0.3

-9%

n.s.


Copper-WB

(ug/dL)

89

+/- 14

91.2

+/- 13

95.9

+/- 17

+5%

0.09

93.9

+/- 10

95.5

+/- 13

+2%

n.s.


Copper-RBC

(ug/g)

0.72

+/- 0.09

0.75

+/- 0.08

0.78

+/- 0.08

+4%

0.06

0.74

+/- 0.08

0.77

+/- 0.08

+4%

n.s.


Iodine-Urine

(ug/mg creatinine)

0.26

+/- 0.2

0.28

+/- 0.26

0.43

+/- 0.27

+54%

0.03*

0.23

+/- 0.15

0.22

+/- 0.15

-5%

n.s.


Iron-RBC

(ug/g)

833

+/- 64

887

+/- 101

806

+/- 54

-9%

0.006

883

+/- 80

826

+/- 51

-7%

0.02


Iron-Serum

(ug/dL)

87

+/- 35

91

+/- 34

88

+/- 46

-3%

n.s.

80

+/- 33

81

+/- 25

+2%

n.s.


Serum Ferritin

36.9

+/- 17

42.1

+/- 23

37.3

+/- 23

-11%

n.s.

41.3

+/- 25.1

33.4

+/- 22

-19%

0.004


Lithium-WB

(ug/L)

3.6

+/- 6

1.82

+/- 0.8

10.6

+/-5.1

+485%

.000001

1.60

+/- 0.7

1.47

+/- 0.7

-8%

n.s.


Magnesium-WB

(mg/dL)

3.64

+/- 0.26

3.44

+/- 0.19

3.62

+/- 0.25

+5%

0.00007

3.65

+/- 0.41

3.81

+/-0.42

+4%

0.03


Magnesium-RBC (ug/g)

47.5

+/- 5

48.6

+/- 7.5

44.9

+/- 4.0

-8%

0.03

49.4

+/- 5.8

47.9

+/- 6.0

-3%

n.s.


Magnesium-Serum

(mg/dL)

2.03

+/- 0.15

1.90

+/- 0.13

1.95

+/- 0.15

+2%

n.s.

1.93

+/- 0.14

1.97

+/- 0.15

+2%

n.s.


Manganese-WB

(ug/L)

11.6

+/- 3

11.0

+/- 3.3

13.6

+/- 4.4

+23%

0.0006

12.0

+/- 4.7

14.5

+/- 5.0

+21%

0.00002


Manganese-RBC (ug/g)

0.018

+/- 0.005

0.019

+/- 0.007

0.019

+/- 0.006

+1%

n.s.

0.020

+/- 0.006

0.019

+/- 0.007

-4%

n.s.


Molybdenum-WB (ug/L)

1.39

+/- 0.3

1.27

+/- 0.23

1.88

+/- 0.9

+48%

0.007*

1.34

+/- 0.3

1.37

+/- 0.3

+3%

n.s.


Molybdenum-RBC (ng/g)

0.98 +/- 0.2

1.01

+/- 0.3

1.32

+/- 0.0007

+31%

0.06*

0.87

+/- 0.26

0.93

+/- 0.2

+7%

n.s.


Phosphorus-RBC (ug/g)

567

+/- 43

587

+/- 73

546

+/- 39

-7%

0.01

598

+/- 48

564

+/-37

-6%

0.002


Phosphorus-Serum

(mg/dL)

4.58

+/- 0.5

4.52

+/- 0.5

4.47

+/- 0.6

-1%

n.s.

4.57

+/- 0.5

4.68

+/- 0.7

+2%

n.s.


Potassium -RBC-mEq/L

76.9

+/- 4.1

78.1

+/- 6.2

75.5

+/- 4.4

-3%

n.s.

81.1

+/- 5.1

77.2

+/- 5.1

-5%

0.01


Potassium-Serum

mEq/L

4.17

+/- 0.3

4.12

+/- 0.3

4.21

+/- 0.3

+2%

n.s.

4.01

+/- 0.3

4.04

+/- 0.3

1%

n.s.


Selenium-WB

(ug/L)

210

+/- 20

209

+/- 25

223

+/- 28

+7%

0.001

211

+/- 39

218

+/- 44

+3%

0.05


Selenium-RBC

(ug/g)

0.23

+/- 0.03

0.251

+/- 0.025

0.235

+/- 0.03

-6%

0.007

0.244

+/- 0.052

0.221

+/- 0.04

-10%

0.002


Sodium-Serum

mEq/L

137

+/- 1

137

+/- 2

137

+/- 1

0%

n.s.

138

+/- 3

138

+/- 2

0%

n.s.


Vanadium-RBC

(ng/g)

0. 22 +/- 0.07

0. 22

+/- 0.09

0. 21

+/- 0.05

-5%

n.s.

0.21

+/- 0.04

0.23

+/- 0.09

+10%

n.s.


Zinc-WB

(ug/dL)

555

+/- 74

546

+/- 70

556

+/- 68

+2%

n.s.

559

+/- 59

567

+/-59

+1%

n.s.


Zinc-RBC

(ug/g)

8.9

+/- 1.4

9.1

+/- 1.5

8.6

+/- 1.2

-5%

n.s.

9.1

+/- 1.1

8.8 +/- 1.2

-3%

n.s.


Non-essential minerals


Boron-RBC

(ug/g)

0.025

+/- 0.007

0.031

+/- 0.015

0.022

+/- 0.008

-30%

0.004

0.025

+/- 0.013

0.019 +/- 0.010

-24%

n.s.


Strontium-WB

(ug/L)

24

+/- 6

21.6

+/- 3.7

22.8

+/-4.5

+6%

n.s.

29.1

+/- 10

28.6

+/-10

-2%

n.s.


Biomarker data was obtained only for the Arizona autism group. The p-value for a t-test comparison of the change in the level is reported. If the p-value is below 0.05, then the result is highlighted.

* The ttest for urinary iodine and WB & RBC Molybdenum was done after a square root transformation of the data, since the initial data was not close to a Gaussian distribution.

Adams et al. BMC Pediatrics 2011 11:111   doi:10.1186/1471-2431-11-111

Open Data