Table 1

Summary of Reported Cases of Epithelial Downgrowth (ED) after Penetrating Keratoplasty (PK)

Author

Previous ocular surgery

PK Indication

Time from PK to ED diagnosis

Clinical features of ED

Diagnosis of ED

Final Anatomic/ Visual Status


Chiou et al [1]

3 PKs, 2 Trabs, 1 CPC

Graft Failure

13 months

Concentric peripheral retrocorneal membrane

Confocal microscopy

BSCVA 20/400


Feder & Krachmer [2]

ICCE

ABK

6 months

Iritis, glaucoma, posterior corneal line

Paracentesis, laser

Graft decompensation, glaucoma

ICCE

PBK

7 months

Iritis, glaucoma

Paracentesis, laser

End-stage glaucoma

ICCE

Fuchs' dystrophy

5 months

Posterior corneal line

Paracentesis, laser

Evisceration

ECCE

KCN

13 years

Iritis

Paracentesis, laser

Phthisis bulbi


Mazow [7]

None

Endothelial dystrophy

5 months

Glaucoma

Histopathologic

Enucleation


Karabatsas [8]

2 PKs

PBK

8 months

Posterior corneal line, glaucoma

Clinical features

Not available


Sugar [3]

PK, ICCE

Graft failure

7 months

Retrocorneal membrane, pre-iris membrane

Histopathologic

Recurrent retrocorneal membrane; CF VA*

ICCE

ABK;Fuchs' dystrophy

2 weeks

Descemet's deposits

Histopathologic

BSCVA 20/200

LK, ICCE

Opacification of lamellar graft

16 months

Pre-iris membrane

Histopathologic

Scarred regraft; VA 10/400

PK, ICCE

Graft failure

6 months

Retrocorneal membrane

Clinical features

Vascularized, edeamatous regraft, VA HM


Leibowitz [9]

2 PKs

Graft failure

1 month

Retrocorneal membrane; anterior chamber epithelial cyst

Histopathologic

Vascularized, opacified regraft


Groh & Naumann [10]

None

KCN

13 months

Anterior chamber epithelial cyst

Clinical features

VA 14/20

None

Lattice corneal dystrophy

47 months

Anterior chamber epithelial cyst

Clinical features

VA 10/20


Wearne [11]

None

Scarring 2° to HSV keratitis

10 years

Anterior chamber epithelial cyst

Clinical features

VA 6/20


Yamaguchi et al. [12]

PK, ICCE

Graft failure

12 months

Retrocorneal membrane

Clinical features and histopathologic

Opacified regraft


Sidrys [13]

ICCE

PBK

3 weeks§

Retrocorneal membrane

Clinical features and histopathologic

VA 6/60Θ


Weiner [14]#

Unknown

Various

Unknown

Retrocorneal membrane, glaucoma

Clinical features and histopathologic

Unknown


Kurz & D'Amico [16]

None

Corneal scar

10 months

None

Histopathologic

Unknown

None

Corneal scar

8 weeks

None

Histopathologic

Enucleation**


Bennett & D'Amico [15]

None

KCN

3 years

Iris epithelial inclusion cyst

Clinical features and histopathologic

S/p sector iridectomy without recurrence


Claoue et al [17]

None

KCN

21 months

Iris epithelial inclusion cyst

Clinical features and histopathologic

S/p sector iridectomy without recurrence


Daneshvar et al. [6]

CE

ABK

1 year

Glaucoma, retrocorneal membrane

Laser, ultrasound biomicroscopy

No recurrence 16 months after repeat PK


BSCVA = best spectacle corrected visual acuity; ABK = aphakic bullous keratopathy; CF = counting fingers; CPC = cyclophotocoagulation; ECCE = extracapsular cataract extraction; HM = hand motions; HSV = herpes simplex virus; ICCE = intracapsular cataract extraction; KCN = keratoconus; LK = lamellar keratectomy; PBK = pseudophakic bullous keratopathy; Trab = trabeculectomy; * limited by ARMD; h/o CME and RD s/p SB; same patient reported again in; 10§ epithelial downgrowth through a cataract wound fistula; Θ limited by CME; same patient reported again in; 12 # 13 patients reported; ** performed after traumatic wound dehiscence and total retinal detachment

Aldave et al. BMC Ophthalmology 2005 5:11   doi:10.1186/1471-2415-5-11

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