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Open Access Research article

Association of systemic and ocular risk factors with neurosensory retinal detachment in diabetic macular edema: a case–control study

Aditi Gupta1, Rajiv Raman1, Vaitheeswaran Kulothungan2 and Tarun Sharma1*

Author Affiliations

1 Shri Bhagwan Mahavir Department of Vitreoretinal Services, Sankara Nethralaya, 18, College Road, Chennai 600 006, Tamil Nadu, India

2 Department of Preventive Medicine and Biostatistics, Sankara Nethralaya, 18, College Road, Chennai, 600 006 Tamil Nadu, India

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BMC Ophthalmology 2014, 14:47  doi:10.1186/1471-2415-14-47

Published: 9 April 2014

Abstract

Background

Diabetic macular edema (DME) with neurosensory retinal detachment (NSD) remains an important cause of visual loss in patients with diabetes. The aim of the study was to elucidate the association of systemic and ocular risk factors with NSD in DME.

Methods

In a retrospective case–control study, we reviewed clinical records of all the subjects with DME seen between January 2010 and December 2010. Cases and controls were selected based on optical coherence tomography and stereoscopic biomicroscopy review. NSD was defined as subfoveal fluid accumulation under detached retina with or without overlying foveal thickening. The association between the presence of NSD, blood pressure, lipid status and various other biochemical parameters was evaluated.

Results

Group I (cases) included 37 eyes of 33 patients having DME with NSD and Group II (controls) included 30 eyes of 21 patients having DME without NSD. Patients ranged in age (mean ± SD) from 50 to 62 years (56.6 +/-6.78) for cases and from 51 to 65 years (58.4+/-7.84) for controls. The duration of diabetes ranged from 4 to 15 year (mean 9.45+/-6.08) among cases and 4 to 14 years (9.7+/-5.12) among controls. Significant risk factors for NSD were high values of systolic and diastolic blood pressure (p = 0.039 and 0.043 respectively).

Conclusion

High systolic and diastolic blood pressures are independent and significant risk factors for NSD in DME.

Keywords:
Diabetic macular edema; Neurosensory retinal detachment; Risk factors; Blood Pressure