Table 2

Comparison of the clinical characteristics between Group 1 (cases in which transparency was restored, n = 37) and Group 2 (cases in which transparency was not restored, n = 21)
Group 1 Group 2 OR P-value
mean ± SD mean ± SD (95% CI)
n (%) n (%)
Age (years) 59.4 ± 15.5 68.3 ± 12.5 0.95 (0.91–1.00) 0.037
Sex
 Male 23 (62.2) 10 (47.6) 1.81 (0.61–5.34) 0.28
 Female 14 (37.8) 11 (52.4) 1.00
Diagnosis before PKP
 Bullous keratopathy 13 (35.1) 8 (38.1) 0.88 (0.29–2.67) 0.82
 Regraft 8 (21.6) 6 (28.6) 0.69 (0.20–2.36) 0.55
 Corneal scar 9 (24.3) 4 (19.0) 1.37 (0.36–5.13) 0.64
 Corneal dystrophy 3 (8.1) 1 (4.8) 1.76 (0.17–18.13) 0.63
 Keratoconus 3 (8.1) 0 (0.0) 1.00
 Corneal ulcer 1 (2.7) 2 (9.5) 0.26 (0.02–3.10) 0.29
Type of surgery
 PKP 27 (73.0) 16 (76.2) 0.84 (0.24–2.91) 0.79
 PKP + ECCE + IOL 9 (24.3) 4 (19.0) 1.37 (0.36–5.13) 0.64
 PKP + IOL suture 1 (2.7) 1 (4.8) 0.56 (0.03–9.37) 0.68
history of glaucoma 8 (21.6) 9 (42.9) 0.37 (0.11-1.18) 0.093
Previous episodes of rejection 4 (10.8) 4 (19.0) 0.51 (0.11–2.32) 0.38
ECD before rejection 1669 ± 747 806 ± 455 1.002 (1.001–1.004) 0.013
Interval between PKP and rejection (months) 33.3 ± 40.0 28.2 ± 30.7 1.00 (0.99–1.02) 0.61
Interval between rejection and treatment with systemic steroids (days) 6.2 ± 5.6 14.5 ± 12.8 0.88 (0.80–0.97) 0.0093
Systemic steroid
 Dexamethasone phosphate 29 (78.4) 18 (85.7) 0.60 (0.14–2.58) 0.50
 Methylprednisolone 8 (21.6) 3 (14.3) 1.66 (0.39–7.07)

ECCE, extracapsular cataract extraction; ECD, endothelial cell density; IOL, intraocular lens; PKP, penetrating keratoplasty; SD, standard deviation.

Yamazoe et al.

Yamazoe et al. BMC Ophthalmology 2013 13:5   doi:10.1186/1471-2415-13-5

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