Table 5

Percentage change in IOP (mmHg) from baseline to week 4 (ANCOVA, PP population)
Latanoprost concentration (μg/mL)
50 75 100 125
N 69 66 71 68
Worse eye
8 a.m. IOP
 LS mean change (mmHg)* −37.6 −35.5 −37.3 −33.5
 Difference in LS mean change ± SEM 2.2 ± 1.7 0.3 ± 1.7 4.1 ± 1.7
 (90% CI) (−0.06, 5.0) (−2.4, 3.1) (1.3, 6.8)
 p-value 0.899 0.581 0.992
Study eye
8 a.m. IOP
 LS mean change (mmHg)* −37.2 −35.0 −36.4 −33.3
 Difference in LS mean change ± SEM 2.2 ± 1.7 0.8 ± 1.6 3.8 ± 1.6
 (90% CI) (−0.6, 4.9) (−1.9, 3.4) (1.1, 6.5)
 p-value 0.906 0.682 0.990

ANCOVA analysis of covariance, CI confidence interval, IOP intraocular pressure, LS least square, PP per protocol, SEM standard error of the mean.

*Adjusting for baseline IOP (covariate) with dose group and center as factors.

Higher concentration minus latanoprost 50 μg/mL; a negative difference in LS mean indicates that the higher concentration has a greater effect than latanoprost 50 μg/mL.

One-sided p-value.

Eveleth et al.

Eveleth et al. BMC Ophthalmology 2012 12:9   doi:10.1186/1471-2415-12-9

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