Email updates

Keep up to date with the latest news and content from BMC Ophthalmology and BioMed Central.

Open Access Highly Accessed Research article

Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters

Degui Wang1, Yuqiang Huang1, Chukai Huang1, Pengfei Wu1, Jianwei Lin1, Yuqian Zheng1, Yi Peng2, Yuanbo Liang2, Jian-Huan Chen12* and Mingzhi Zhang1*

Author affiliations

1 Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China

2 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China

For all author emails, please log on.

Citation and License

BMC Ophthalmology 2012, 12:59  doi:10.1186/1471-2415-12-59

Published: 27 November 2012

Abstract

Background

To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort.

Methods

In a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression.

Results

In either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05).

Conclusions

Although cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.

Keywords:
Primary open angle glaucoma; Cigarette smoking; Central corneal thickness; Vertical cup-to-disc ratio; Intraocular pressure