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Open Access Research article

Role of Heat Shock Protein 47 in Transdifferentiation of Human Tenon's Fibroblasts to Myofibroblasts

Samin Hong1, Kyoungsoo Park12, Jin Hyoung Kim1, Sueng-Han Han1, Jong Bok Lee1 and Gong Je Seong1*

Author Affiliations

1 Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea

2 Siloam Eye Hospital, 181 Deungchon-ro, Gangseo-gu, Seoul, 156-032, Republic of Korea

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BMC Ophthalmology 2012, 12:49  doi:10.1186/1471-2415-12-49

Published: 11 September 2012

Additional files

Additional file 1:

Western immunoblots of the scrambled siRNA-introduced fibroblasts for heat shock protein 47 (Hsp47) (A), α smooth muscle actin (αSMA) (B), and β-actin (C). siRNA Sc = scrambled siRNA; TGF-β1 = transforming growth factor-β1.

Format: TIFF Size: 236KB Download file

Open Data

Additional file 2:

Immunefluorescence of human Tenon’s fibroblasts for heat shock protein 47 (Hsp47). (A) No treatment control; (B) TGF-β1 treatment. Nuclei were counterstained with 4',6-diamidino-2-phenylindole (DAPI).

Format: TIFF Size: 1.5MB Download file

Open Data