Table 5

Multivariate analyses of factors associated with survival and recurrence

Hazard ratio (95%CI)

P

OS

AFP(ng/ml) (≤ 20 vs. >20)

1.320 (0.666-2.615)

0.426

γ-GT(U/I) (≤ 54 vs. >54)

2.098 (1.073-4.103)

0.030

Tumor differentiation (I+II vs. III+IV)

1.228 (0.661-2.279)

0.516

Tumor size (cm)

1.102 (1.016-1.196)

0.020

Vascular invasion (no vs. yes)

4.351 (1.992-9.500)

0.001

Capsule (complete vs. no)

0.676 (0.332-1.375)

0.280

HIF-1α mRNA (low vs. high)

2.167 (1.185-3.965)

0.012

COX-2 mRNA (low vs. high)

2.557 (1.355-4.824)

0.004

MMP7 mRNA (low vs. high)

2.287 (1.217-4.301)

0.010

PDGFRA mRNA (low vs. high)

2.320 (1.225-4.394)

0.010

HIF-1α protein (low vs. high)

2.108 (1.120-3.969)

0.021

DFS

Age (year)

0.990 (0.963-1.018)

0.475

AFP(ng/ml) (≤ 20 vs. >20)

1.707 (0.903-3.227)

0.100

Tumor size (cm)

1.090 (0.997-1.191)

0.060

Tumor number (single vs. multiple)

3.324 (1.818-6.079)

0.001

Vascular invasion (no vs. yes)

2.453 (1.192-5.047)

0.015

Encapsulation (complete vs. no)

1.573 (0.781-3.168)

0.204

HIF-1α mRNA (low vs. high)

2.359 (1.325-4.201)

0.004

COX-2 mRNA (low vs. high)

2.170 (1.201-3.921)

0.010

MMP7 mRNA (low vs. high)

1.499 (0.830-2.707)

0.179

VEGF mRNA (low vs. high)

1.702 (0.936-3.094)

0.081

PDGFRA mRNA (low vs. high)

1.910 (1.038-3.514)

0.038

HIF-1α protein (low vs. high)

2.265 (1.251-4.009)

0.007

Detailed legends: The P values were calculated using multivariate Cox proportional hazards analysis. Variables were adopted for their prognostic significance by univariate analysis and no significant correlation between each other. COX-2 mRNA, PDGFRA mRNA, MMP7 mRNA, VEGF mRNA and HIF-1α protein were presented in different multivariable analysis respectively. (For details see Additional files 3, 4, 5, 6, 7 and 8)

Dai et al. BMC Cancer 2009 9:418   doi:10.1186/1471-2407-9-418