Research article
Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery
-
* Corresponding author: Jia Fan jiafan99@yahoo.com
- † Equal contributors
1 Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai, PR China
2 Institute of Biomedical Sciences, Fudan University, Shanghai, PR China
3 Center for Evidence Based Medicine, Fudan University, Shanghai, PR China
BMC Cancer 2009, 9:418 doi:10.1186/1471-2407-9-418
Published: 1 December 2009Additional files
Additional file 1:
Figure S1: Relative expression of HIF-1α, COX-2, MMP7, MMP9, VEGF, PDGFRA and MYC with the cut-off value determined by the X-tile software. The blue dots show the relative value of mRNA expression. The red lines show the cut-off value.
Format: DOC Size: 65KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 2:
Table S1: Degree of HIF-1α immunohistochemistry in tissue array of HCC. I, no staining; II, nuclear staining in less than 10% of cells and/or with weak cytoplasmic staining; III, nuclear staining in 10%-50% of cells and/or with moderate cytoplasmic staining; IV, nuclear staining in more than 50% of cells and/or with strong cytoplasmic staining.
Format: DOC Size: 33KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 3:
Figure S2: Kaplan-Meier analysis of OS and DFS for COX-2, MMP7, MMP9, VEGF, PDGFRA and MYC mRNA
Format: DOC Size: 938KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 4:
Table S3: Multivariate analyses of variables associated with survival and recurrence including mRNA expression of COX-2 as co-variable
Format: DOC Size: 38KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 5:
Table S4: Multivariate analyses of variables associated with survival and recurrence including mRNA expression of PDGFRA as co-variable
Format: DOC Size: 38KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 6:
Table S5: Multivariate analyses of variables associated with survival and recurrence including mRNA expression of MMP7 as co-variable
Format: DOC Size: 37KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 7:
Table S6: Multivariate analyses of variables associated with survival and recurrence including protein expression of HIF-1α as co-variable. (P = 0.021 for OS, P = 0.007 for DFS).
Format: DOC Size: 38KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 8:
Table S7: Multivariate analyses of variables associated with survival and recurrence including mRNA expression of VEGF as co-variable. (P = 0.081 for DFS).
Format: DOC Size: 32KB Download file
This file can be viewed with: Microsoft Word Viewer
Additional file 9:
Table S2: Correlations between HIF-1α mRNA and protein expression.
Format: DOC Size: 29KB Download file
This file can be viewed with: Microsoft Word Viewer