Table 2

Incidence rate ratio for colorectal cancer for the studied gene polymorphisms.

NCase

NSub-cohort

IRRa

(95% CI)

IRRb

(95% CI)

P-valuec


MDR1 G-rs3789243-A

GG

81

224

1.00

-

1.00

-

0.03

GA

194

365

1.55

(1.13-2.12)

1.55

(1.12-2.14)

AA

84

176

1.43

(0.98-2.08)

1.45

(0.99-2.13)

GA and AA

278

541

1.51

(1.12-2.04)

1.52

(1.12-2.06)

MDR1 C3435T

CC

73

118

1.00

-

1.00

-

0.11

CT

174

385

0.69

(0.49-0.99)

0.74

(0.51-1.07)

TT

112

262

0.66

(0.45-0.96)

0.66

(0.45-0.98)

CT and TT

286

647

0.68

(0.48-0.95)

0.71

(0.50-1.00)

COX-2 G-765C

GG

267

566

1.00

-

1.00

-

0.91

CG

83

186

1.02

(0.75-1.39)

1.03

(0.75-1.41)

CC

9

13

1.45

(0.61-3.48)

1.21

(0.49-2.98)

CG and CC

92

199

1.05

(0.78-1.41)

1.04

(0.77-1.42)

COX-2 A-1195G

AA

230

482

1.00

-

1.00

-

0.88

AG

116

258

0.94

(0.71-1.24)

0.93

(0.70-1.23)

GG

13

25

0.90

(0.44-1.85)

0.94

(0.45-1.95)

AG and GG

129

283

0.93

(0.71-1.22)

0.93

(0.71-1.23)

COX-2 T8473C

TT

147

315

1.00

-

1.00

-

0.37

CT

178

355

1.12

(0.85-1.48)

1.11

(0.83-1.47)

CC

34

95

0.82

(0.52-1.29)

0.81

(0.51-1.28)

CT and CC

212

450

1.06

(0.81-1.38)

1.05

(0.80-1.37)

BRCP C421A

CC

296

592

1.00

-

1.00

-

0.16

CA

58

161

0.72

(0.51-1.01)

0.71

(0.50-1.01)

AA

5

12

1.10

(0.38-3.21)

1.17

(0.39-3.57)

CA and AA

63

173

0.74

(0.53-1.03)

0.73

(0.52-1.04)


aCrude (adjusted for age and sex).

bAdjusted for status of HRT (women only), smoking status, alcohol, dietary fibre, red meat, BMI and NSAID.

cp-value for trend for the fully adjusted estimates.

Andersen et al. BMC Cancer 2009 9:407   doi:10.1186/1471-2407-9-407

Open Data