Research article
Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma
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* Corresponding author: Zhenfeng Duan zduan@partners.org
1 Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
2 Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
3 Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
4 Current address: Department of Radiology, Center for Molecular & Functional Imaging, University of California at San Francisco, San Francisco, CA 94107, USA
BMC Cancer 2009, 9:399 doi:10.1186/1471-2407-9-399
Published: 16 November 2009Additional files
Additional file 1:
The effect of nanoparticle on KHOS and KHOSR2 was analyzed. The dextran nanoparticle was non-cytotoxic by itself at a dose utilized in this study. The experiment was repeated four times in triplicate.
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Additional file 2:
The effect of nanoparticle on cleavage of PARP was analyzed using western blot assay. The dextran nanoparticle itself did not cause cleavage of PARP on KHOS or KHOSR2 at a dose utilized in this study.
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