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Open Access Research article

No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

Ellen L Goode1*, Csilla Szabo4, Ludmila Prokunina-Olsson2, Robert A Vierkant1, Zachary S Fredericksen1, Francis S Collins3, Kristin L White1, Michele Schmidt1, Brooke L Fridley1 and Fergus J Couch4

  • * Corresponding author: Ellen L Goode egoode@mayo.edu

  • † Equal contributors

Author Affiliations

1 Health Sciences Research, Mayo Clinic College of Medicine, Rochester, USA

2 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA

3 Office of the Director, National Institutes of Health, Bethesda, USA

4 Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, USA

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BMC Cancer 2009, 9:312  doi:10.1186/1471-2407-9-312

Published: 4 September 2009

Abstract

Background

TCF7L2 is a transcription factor involved in Wnt/β-catenin signaling which has a variant known to be associated with risk of Type 2 diabetes and, in some studies, with risk of certain cancers, including familial breast cancer. No studies of ovarian cancer have been reported to date.

Methods

Two clinic-based case-control studies at the Mayo Clinic were assessed including 798 breast cancer cases, 843 breast cancer controls, 391 ovarian cancer cases, and 458 ovarian cancer controls. Genotyping at TCF7L2 rs12255372 used a 5' endonuclease assay, and statistical analysis used logistic regression among participants as a whole and among a priori-defined subsets.

Results

No associations with risk of breast or ovarian cancer were observed (ordinal model, p = 0.62 and p = 0.75, respectively). In addition, no associations were observed among sub-groups defined by age, BMI, family history, stage, grade, histology, or tumor behavior.

Conclusion

Although the biology of the Wnt/β-catenin signaling pathway and prior association between rs12255372 and numerous phenotypes warranted examination of this TCF7L2 SNP, no compelling evidence for association with breast or ovarian cancer was observed.