Table 4 |
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|
Association between GNRHR haplotypes and breast cancer risk in the BPC3 study. |
||||
|
Haplotype |
Cases (%) |
Controls (%) |
OR (95% CI)a |
p value |
|
|
||||
|
Block 1 |
||||
|
hAGA |
2,426 (43) |
3,161 (42) |
1.00 (ref.) |
|
|
hGGT |
2,060 (36) |
2,806 (37) |
0.98 (0.93–1.03) |
0.491 |
|
hGAT |
473 (8) |
620 (8) |
1.02 (0.93–1.11) |
0.712 |
|
hAGT |
397 (7) |
557 (7) |
0.96 (0.87–1.06) |
0.433 |
|
hGGA |
307 (5) |
400 (5) |
0.97 (0.87–1.07) |
0.522 |
|
Freq<3% |
4 (<1) |
6 (<1) |
0.83 (0.31–2.25) |
0.720 |
|
Block 2 |
||||
|
hATTA |
2,997 (53) |
3,908 (52) |
1.00 (ref.) |
|
|
hGCTG |
1,178 (21) |
1,630 (22) |
0.99 (0.92–1.06) |
0.342 |
|
hATCG |
667 (12) |
937 (12) |
1.00 (0.92–1.09) |
0.731 |
|
hATTG |
478 (8) |
633 (8) |
1.01 (0.89–1.14) |
0.949 |
|
hACTG |
177 (3) |
214 (3) |
0.98 (0.85–1.15) |
0.862 |
|
hGCCG |
150 (3) |
206 (3) |
1.11 (0.76–1.62) |
0.836 |
|
Freq<3% |
21 (<1) |
22 (<1) |
0.98 (0.93–1.03) |
0.579 |
|
|
||||
|
aOdds ratios and 95% confidence intervals, calculated by unadjusted logistic regression analysis conditional on the matching variables |
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|
Canzian et al. BMC Cancer 2009 9:257 doi:10.1186/1471-2407-9-257 |
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