BMC Cancer

official impact factor 3.15

Open Access Research article

Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

Federico Canzian1*, Rudolf Kaaks1, David G Cox2, Katherine D Henderson3,4, Brian E Henderson3, Christine Berg5, Sheila Bingham6, Heiner Boeing7, Julie Buring8, Eugenia E Calle9, Stephen Chanock5, Francoise Clavel-Chapelon10, Laure Dossus1, Heather S Feigelson9, Christopher A Haiman3, Susan E Hankinson8, Robert Hoover5, David J Hunter2, Claudine Isaacs11, Per Lenner12, Eiliv Lund13, Kim Overvad14, Domenico Palli15, Celeste L Pearce3, Jose R Quiros16, Elio Riboli17, Daniel O Stram3, Gilles Thomas5, Michael J Thun9, Dimitrios Trichopoulos18, Carla H van Gils19 and Regina G Ziegler5

Author Affiliations

1 German Cancer Research Center (DKFZ), Heidelberg, Germany

2 Harvard School of Public Health, Boston, MA, USA

3 University of Southern California, Los Angeles, CA, USA

4 Beckman Research Institute of the City of Hope National Medical Center, Duarte, CA, USA

5 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA

6 MRC Dunn Human Nutrition Unit, Cambridge, UK

7 Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

8 Harvard Medical School, Boston, MA, USA

9 American Cancer Society, Atlanta, GA, USA

10 INSERM, Institut Gustave Roussy, Villejuif, France

11 Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, USA

12 Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden

13 Institute of Community Medicine, University of Tromsø, Tromsø, Norway

14 Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark

15 Molecular and Nutritional Epidemiology Unit, CSPO-Scientific Institute of Tuscany, Florence, Italy

16 Public Health and Health Planning Directorate, Asturias, Spain

17 Imperial College, London, UK

18 Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Athens, Greece

19 Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands

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BMC Cancer 2009, 9:257 doi:10.1186/1471-2407-9-257

Published: 29 July 2009

Additional files

Additional file 1:

Detailed results of associations between serum concentrations of steroid hormones and SNPs.

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Open Data