Table 4

Logistic regression analysis to identify predictors of BRCA mutations

Characteristics

No. of cases

BRCA+ carriers

OR (95% CI)

P

Age of Onset

< 45 years

139

21 (15%)

1.8 (1.05–4.28)

0.046

> 45 years

209

14 (7%)

Risk criteria

high-risk family

131

23 (18%)

3.2 (1.51–6.67)

0.002

no high risk family

217

12 (6%)

Ovarian cancer in family

presence

23

6 (26%)

3.7 (1.44–9.40)

0.006

absence

244

27 (11%)

Bilaterality

presence

36

8 (22%)

2.4 (1.05–5.39)

0.038

absence

228

25 (11%)

T

T1

151

12 (8%)

2.23 (0.57–8.82)

0.251

T2

70

10 (14%)

T3-4

26

4 (15%)

N

N-

126

15 (12%)

1.02 (0.39–2.67)

0.963

N+

112

13 (12%)

M

M0

201

20 (10%)

1.33 (0.15–11.7)

0.797

M1

24

3 (12%)

Tumor Grading

G1-2

171

9 (5%)

11.3 (3.38–37.6)

< 0.001

G3-4

33

12 (36%)

Estrogen Receptor (ER)

ER-

55

16 (29%)

0.18 (0.06–0.53)

0.002

ER+

102

10 (10%)

Progesteron Receptor (PR)

PR-

81

21 (26%)

0.22 (0.07–0.66)

0.007

PR+

67

6 (9%)

Palomba et al. BMC Cancer 2009 9:245   doi:10.1186/1471-2407-9-245