Table 2

Individual local tumor response.

Macroscopic tumor response

Patient

Initial tumor size

(% tumor of intestinal lumen)

after 3–4 months of therapy

best response

Complete luminal response of the primary

(group I)

Normal mucosa (Ia)

Pat. 07

85%

30%

30%

Pat. 09

85%

0%

0%

death

related to metastasis

n = 1

0 alive

related to other causes

n = 1

Adenomatous tissue (Ib)

Pat. 05*

85%

70%

30%

Pat. 10*

R: 85%/L: 50%

R: 60%/L:

R: 60%/L: OP

Pat. 12

85%

30%

5%

Pat. 15*

95%

20%

40%

85%

death

related to metastasis

n = 3

0 alive

related to other causes

n = 1

Relapse after therapeutic break (group II)

Initially no tumor cells at biopsy

Pat. 03

80%

60%

0%

Pat. 06*

85%

30%

30%

Pat. 08*

100%

85%

55%

Pat. 20*

75%

25%

25%

death

related to metastasis

n = 1

3 alive

related to other causes

n = 0

Partial macros-copic response of the primary

(group III)

Histologically confirmed tumor tissue

Pat. 01*

85%

85%

85%

Pat. 02*

90%

85%

70%

Pat. 04*

85%

80%

80%

Pat. 11*

85%

75%

75%

Pat. 13*

100%

85%

85%

Pat. 14

60%

40%

OP

Pat. 16*

60%

30%

20%

Pat. 17*

100%

85%

85%

Pat. 18*

90%

85%

85%

Pat. 19*

80%

70%

65%

death

related to metastasis

n = 8

2 alive

related to other causes

n = 0

* incomplete = reduced amount of therapy or therapeutic break

Cameron et al. BMC Cancer 2009 9:218   doi:10.1186/1471-2407-9-218