Research article
A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example
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* Corresponding author: Christi J van Asperen asperen@lumc.nl
- † Equal contributors
1 Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
2 Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
3 Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
4 Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
5 Department of Genetics, University Medical Center, Groningen University, Groningen, The Netherlands
6 Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
7 Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
8 Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
9 Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
10 Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
11 Department of Clinical Genetics, University Medical Center, Maastricht, The Netherlands
12 Department of Genetics and Cell Biology, University Medical Center, Maastricht, The Netherlands
BMC Cancer 2009, 9:211 doi:10.1186/1471-2407-9-211
Published: 29 June 2009Additional files
Additional file 1:
Additional Tables and Figures Mohammadi. This file contains additional tables 1–3 and additional figures 1–5.
Format: PDF Size: 282KB Download file
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Additional file 2:
Instruction method Mohammadi. This document contains a description on the use of the co-segregation analysis website with detailed instruction on the preparation of the input file that contains the pedigree information.
Format: PDF Size: 199KB Download file
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