Table 3

Putative target genes for tumorigenesis and tumor progression in recurrent copy number changes of the 16 ESFT patients included in the integration analysis.

Symbol

Name

Cytoband

Location¹

Correlation

p-value

Copy number status²

q-value

Functional information

HEATR3

HEAT repeat containing 3

16q12.1

48697286–48697733

0,876

2,2E-16

Deleted

6,05E-13

NA

TRAFD1

TRAF-type zinc finger domain containing 1

12q24.12

111075038–111075556

0,853

2,2E-16

Gained

6,05E-13

[47]

C1orf131

Chromosome 1 open reading frame 131

1q42.2

229426179–229426672

0,850

2,2E-16

Unspecified

6,05E-13

NA

HDGF

Hepatoma-derived growth factor

1q21-q23

154978607–154979115

0,844

1,5E-05

Gained

0,024182394

[34,36-38]

DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

12p13.1

12873623– 12874134

0,844

1,5E-05

Gained

0,024182394

[48]

GIGYF2

GRB10 interacting GYF protein 2

2q37.1

233431003–233431539

0,838

3,5E-05

Unspecified

0,047741159

[49-51]

C2orf49

Chromosome 2 open reading frame 49

2q12.2

105331075–105331416

0,832

5,9E-05

Unspecified

0,069391132

NA

TMEM63A

Transmembrane protein 63A

1q42.12

224110806–224111244

0,829

7,3E-05

Gained

0,07491325

NA

WDR67

WD repeat domain 67

8q24.13

124233227–124233523

0,826

8,8E-05

Gained

0,080319015

NA

GSDMD1

Gasdermin D

8q24.3

144710202–144710602

-0,821

1,3E-04

Gained

0,107927089

NA

GPATCH2

G patch domain containing 2

1q41

215848737–215849264

0,812

1,8E-04

Unspecified

0,137376561

NA

WSB2

WD repeat and SOCS box-containing 2

12q24.23

116955326–116955682

0,809

2,1E-04

Unspecified

0,142275217

[42]

CACNA1C

Calcium channel, voltage-dependent, L type, alpha 1C subunit

12p13.3

2670999–2671234

-0,803

2,7E-04

Deleted

0,160672631

[40,41]

KRT79

Keratin 79

12q13.13

51501640–51502010

-0,800

3,0E-04

Unspecified

0,160672631

NA

PPHLN1

Periphilin 1

12q12

41121456–41121979

0,797

3,2E-04

Gained

0,160672631

[43,44]

C1orf107

Chromosome 1 open reading frame 107

1q32.2

208096981–208097464

0,794

3,5E-04

Gained

0,160672631

NA

FBXL14

F-box and leucine-rich repeat protein 14

12p13.33

1570852–1571348

0,794

3,5E-04

Unspecified

0,160672631

NA

ANKRD11

Ankyrin repeat domain 11

16q24.3

87999533–87999771

0,794

3,5E-04

Deleted

0,160672631

[45,52]

HEATR1

HEAT repeat containing 1

1q43

234815741–234816376

0,791

3,9E-04

Gained

0,160672631

NA

COG2

Component of oligomeric golgi complex 2

1q42.2

228895774–228896323

0,791

3,9E-04

Gained

0,160672631

[39]

¹Location of the Affymetrix target sequence using BLAST algorithm. ²Copy number status = characterization of the copy number status in the whole patient set; unspecified indicates that both amplifications and deletions were found. NA = not available.

Savola et al. BMC Cancer 2009 9:17   doi:10.1186/1471-2407-9-17