Table 2

Numbers of cases aged 0–14 years, age-standardized rates (per million population) and 95% CIs, average annual percentage rate changes and 95% CIs, by diagnosis, sex and time period and test for sex-difference in temporal trend (P-value)




1968–1980

1981–1993

1994–2005
% Ann. Inc
M/F diff

CNS tumours
Male
134
28.5 (23.6,33.4)
115
29.9 (24.4,35.4)
133
38.4 (31.8,45.0)
1.5 (0.5,2.5)
0.74

Female
116
26.2 (21.3,31.0)
91
25.1 (19.9,30.3)
102
32.7 (26.3,39.2)
1.2 (0.2,2.2)

Ependymomas
Male
18
4.3 (2.5,6.8)
17
4.7 (2.7,7.5)
16
4.9 (2.8,8.0)
0.7 (-1.7,3.2)
0.61

Female
10
2.4 (1.2,4.5)
6
1.6 (0.6,3.5)
5
1.9 (0.6,4.5)
-0.5 (-4.6,3.6)

Astrocytomas
Male
38
7.9 (5.4,10.5)
44
11.1 (7.8,14.4)
55
15.5 (11.3,19.6)
3.1 (1.7,4.6)
0.33

Female
36
8.1 (5.4,10.8)
29
7.9 (5.3,11.4)
61
19.5 (14.5,24.5)
4.4 (2.3,6.6)

PNET
Male
35
7.5 (4.9,10.0)
16
4.4 (2.5,7.2)
27
8.1 (5.3,11.8)
0.6 (-1.6,2.9)
0.86

Female
16
3.8 (2.1,6.1)
15
4.3 (2.4,7.1)
14
4.7 (2.5,7.8)
0.9 (-1.7,3.6)

Other gliomas
Male
13
2.9 (1.5,5.0)
10
2.6 (1.2,4.7)
11
3.1 (1.5,5.6)
0.7 (-2.4,3.9)
0.42

Female
15
3.4 (1.9,5.6)
9
2.6 (1.2,4.9)
10
2.9 (1.4,5.4)
-1.0 (-3.7,1.7)

Sympathetic nervous system tumours
Male
32
7.4 (4.8,10.0)
43
12.6 (8.9,16.4)
27
9.6 (6.3,14.0)
0.9 (-0.5,2.4)
0.29

Female
25
6.9 (4.5,10.2)
34
10.3 (6.8,13.8)
36
13.3 (8.9,17.6)
2.2 (0.4,3.9)

Retinoblastoma
Male
16
4.2 (2.4,6.8)
12
3.6 (1.9,6.3)
10
3.6 (1.7,6.6)
-0.3 (-3.6,3.1)
0.42

Female
26
7.2 (4.7,10.5)
17
5.4 (3.1,8.6)
7
2.7 (1.1,5.6)
-2.1 (-5.0,0.8)

Renal tumours
Male
28
6.8 (4.5,9.9)
18
5.1 (3.0,8.0)
25
9.0 (5.8,13.3)
0.5 (-1.5,2.6)
0.86

Female
31
8.3 (5.3,11.2)
29
8.8 (5.9,12.7)
25
9.4 (6.1,13.9)
0.3 (-1.5,2.1)

Hepatoblastomas
Male
1
0.3 (0.0,1.5)
1
0.3 (0.0,1.7)
5
1.9 (0.6,4.4)
7.3 (-0.2,14.9)
0.18

Female
5
1.3 (0.4,3.0)
2
0.6 (0.1,2.3)
3
1.2 (0.2,3.4)
0.5 (-5.5,6.6)

Bone tumours
Male
30
5.3 (3.4,7.2)
17
4.0 (2.3,6.4)
18
4.6 (2.7,7.3)
0.3 (-2.1,2.7)
0.58

Female
21
4.1 (2.5,6.3)
21
5.1 (3.1,7.8)
14
3.8 (2.1,6.4)
-0.7 (-3.3,1.9)

Osteosarcoma
Male
18
3.1 (1.9,5.0)
8
1.9 (0.8,3.8)
8
2.0 (0.9,3.9)
-0.9 (-4.3,2.6)
0.80

Female
16
3.1 (1.8,5.1)
12
2.9 (1.5,5.0)
9
2.5 (1.1,4.7)
-1.5 (-4.2,1.3)

Ewing's sarcoma
Male
12
2.2 (1.1,3.8)
9
2.0 (0.9,3.9)
8
2.0 (0.9,4.0)
0.3 (-2.4,3.0)
0.94

Female
4
0.8 (0.2,2.2)
9
2.2 (1.0,4.2)
3
0.8 (0.2,2.4)
0.1 (-4.9,5.1)

Soft tissue sarcomas
Male
45
9.6 (6.7,12.4)
46
12.5 (8.9,16.2)
36
11.2 (7.5,14.9)
1.3 (-0.2,2.8)
0.70

Female
28
6.0 (4.0,8.7)
22
5.8 (3.6,8.8)
22
7.0 (4.4,10.7)
0.8 (-1.2,2.9)

Rhabdomyosarcoma
Male
24
5.4 (3.4,8.1)
26
7.2 (4.7,10.6)
25
8.3 (5.3,12.3)
2.4 (0.2,4.5)
0.09

Female
19
4.3 (2.5,6.7)
10
2.7 (1.3,5.1)
10
3.7 (1.7,6.7)
-0.4 (-2.7,1.9)

Other
Male
21
4.2 (2.6,6.4)
20
5.3 (3.2,8.2)
11
2.9 (1.4,5.2)
-0.4 (-2.9,2.1)
0.19

Female
9
1.7 (0.8,3.3)
12
3.1 (1.6,5.4)
12
3.4 (1.7,5.9)
2.5 (-1.1,6.0)

Germ cell tumours
Male
17
4.4 (2.5,7.0)
18
5.1 (3.0,8.1)
20
6.5 (4.0,10.2)
2.1 (-0.7,4.8)
0.02

Female
8
1.8 (0.7,3.5)
20
5.7 (3.5,8.9)
32
10.6 (6.9,14.4)
6.2 (4.1,8.3)

Gonadal
Male
13
3.4 (1.8,5.8)
13
3.9 (2.1,6.6)
6
2.1 (0.8,4.6)
-1.1 (-4.9,2.7)
0.001

Female
2
0.4 (0.0,1.3)
2
0.5 (0.1,1.8)
14
4.0 (2.1,6.7)
8.6 (4.3,12.9)

Non-gonadal
Male
4
1.0 (0.3,2.5)
5
1.2 (0.4,2.9)
14
4.4 (2.4,7.5)
7.2 (2.6,11.8)
0.50

Female
6
1.4 (0.5,3.1)
18
5.2 (3.1,8.3)
18
6.6 (3.9,10.5)
5.4 (2.8,7.9)

Carcinomas
Male
11
2.0 (1.0,3.7)
13
3.0 (1.6,5.1)
15
4.2 (2.3,6.9)
3.2 (0.1,6.3)
0.31

Female
17
3.8 (2.2,6.1)
20
5.0 (3.0,7.7)
17
5.0 (2.9,8.0)
1.1 (-1.5,3.7)

Thyroid
Male
2
0.4 (0.0,1.3)
2
0.5 (0.1,1.7)
5
1.3 (0.4,3.0)
5.9 (-0.4,12.2)
0.07

Female
4
0.9 (0.2,2.4)
3
0.7 (0.1,2.0)
2
0.6 (0.1,2.0)
-1.8 (-7.1,3.4)

Melanoma
Male
2
0.3 (0.0,1.2)
3
0.7 (0.1,2.0)
2
0.6 (0.1,2.3)
4.3 (-2.8,11.4)
0.81

Female
3
0.7 (0.1,2.2)
8
2.1 (0.9,4.1)
5
1.6 (0.5,3.7)
3.1 (-2.7,9.0)

Skin
Male
0
-
2
0.4 (0.1,1.5)
2
0.5 (0.1,1.9)
9.6 (0.0,19.2)
0.46

Female
0
-
2
0.5 (0.1,1.6)
2
0.5 (0.1,1.8)
4.5 (-4.8,13.8)

Breast
Male
0
-
0
-
0
-
-
-

Female
0
-
0
-
0
-
-

Genital/other reproductive
Male
0
-
0
-
0
-
-
-

Female
0
-
1
0.3 (0.0,1.8)
0
-
2.9 (-15.1,20.9)

Lung and bronchial
Male
1
0.2 (0.0,1.1)
0
-
0
-
-12.1 (-25.9,1.6)
0.12

Female
1
0.2 (0.0,1.0)
0
-
1
0.3 (0.0,1.4)
2.8 (-9.6,15.2)

Colorectal
Male
0
-
0
-
0
-
-
-

Female
1
0.2 (0.0,1.0)
0
-
1
0.3 (0.0,1.4)
2.5 (-9.9,14.8)


TOTAL
Male
314
68.6 (60.8,76.3)
283
76.1 (67.1,85.0)
289
89.0 (78.6,99.4)
1.3 (0.7,1.9)
0.84

Female
277
65.4 (57.6,73.2)
256
71.8 (62.9,80.7)
258
85.7 (75.0,96.3)
1.2 (0.5,2.0)


Figures are counts, ASRs with 95% CIs, Annual Percentage Change in ASR with 95% CIs (estimated from linear regression model) and p value for testing M/F difference in trend (obtained from year *sex interaction term in linear regression model)

Magnanti et al. BMC Cancer 2008 8:89   doi:10.1186/1471-2407-8-89