Table 5

Gene name, description, and function of the 14-gene prognostic signature and the overlap with previously reported signatures

Gene

Paik et al

van't Veer et al

Dai et al

Gene Description

Gene Function


BUB1

x

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)

cell cycle


CCNB1

x

cyclin B1

regulation of cell cycle


CENPA

x

x

centromere protein A, 17kDa

chromosome organization and biogenesis (sensu Eukarya), nucleosome assembly


DC13

x

DC13 protein

assembly of cytochrome oxidase


DIAPH3

x

x

diaphanous homolog 3 (Drosophila)

actin cytoskeleton organization and biogenesis


MELK

x

maternal embryonic leucine zipper kinase

protein amino acid phosphorylation, ATP binding


MYBL2

x

v-myb myeloblastosis viral oncogene homolog (avian)-like 2

anti-apoptosis, regulation of cell cycle, development


ORC6L

x

x

origin recognition complex, subunit 6 homolog-like (yeast)

DNA replication


PKMYT1

x

membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

protein amino acid phosphorylation, regulation of cyclin dependent protein kinase activity


PRR11

x

proline rich 11

E2F transcription factor taget gene, regulation of cell cycle


RACGAP1

x

Rac GTPase activating protein 1

electron transport


RFC4

x

replication factor C (activator 1) 4, 37kDa

DNA replication


TK1

x

thymidine kinase 1, soluble

DNA metabolism


UBE2S

x

ubiquitin-conjugating enzyme E2S

ubiquitin cycle


Tutt et al. BMC Cancer 2008 8:339   doi:10.1186/1471-2407-8-339

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