Table 3

Univariate and multivariate Cox proportional analyses of overall survival

Univariate analysis

Multivariate analysis



Study

Variable

Hazard ratio

(95% CI)

p-value

Hazard ratio

(95% CI)

p-value


Training set

(untreated set)

14-gene signature

2.48 (1.42–4.32)

0.001

2.00 (1.05–3.83)

0.036

Age

1.08 (1.05–1.11)

<0.0001

1.08 (1.05–1.11)

<.0001

Tumor size

1.42 (0.85–2.39)

0.181

1.00 (0.56–1.78)

0.994

Grade 2

1.41 (0.83–2.40)

0.210

1.44 (0.80–2.59)

0.223

Grade 3

0.80 (0.11–5.93)

0.830

1.15 (0.15–9.08)

0.897


Validation set

(untreated set)

14-gene signature

2.26 (1.51–3.38)

<0.0001

1.97 (1.28–3.04)

0.002

Age

1.06 (1.05–1.08)

<0.0001

1.06 (1.04–1.08)

<.0001

Tumor size

1.61 (1.27–2.03)

<0.0001

1.07 (0.84–1.38)

0.571

Grade 2

2.42 (1.35–4.34)

0.003

1.47 (0.80–2.70)

0.218

Grade 3

2.95 (1.54–5.63)

0.001

1.32 (0.65–2.66)

0.442


Tutt et al. BMC Cancer 2008 8:339   doi:10.1186/1471-2407-8-339

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