Additional file 1.

Concordance for ER status by immunhistochemistry and RT-PCR. We evaluated the concordance of ER status determined by RT-PCR and IHC for the Guy's untreated patients. Of the 287 patients, 97.6% and 96.9% were ER-positive by IHC and RT-PCR assay, respectively. The cutoff point for ER positivity of RT-PCR assay was prespecified as 1.0 based on prior studies [ref. [1]]. The concordance between RT-PCR and IHC results was high. The Kappa coefficient and 95% confidence limits were 0.80 (0.57, 1.00).

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Tutt et al. BMC Cancer 2008 8:339   doi:10.1186/1471-2407-8-339