Table 1

Distribution of Leptin receptor (LEPR) alleles and genotypes in relation to breast cancer risk (unconditional logistic regression)

Cases

Controls

OR (95% CI)

P-value

OR (95% CI)*

P-value


All women

(n = 209)

(n = 209)

Allele frequencies

LEPR (Gln)

0.49

0.51

LEPR (Arg)

0.51

0.49

Genotype frequencies

LEPR (Gln/Gln)

46 (22.0)

56 (26.8)

1.0

LEPR (Gln/Arg)

107 (51.2)

107 (51.2)

1.2 (0.8–2.0)

0.42

1.2 (0.8–2.0)

0.40

LEPR (Arg/Arg)

56 (26.8)

46 (22.0)

1.5 (0.8–2.6)

0.16

1.6 (0.9–3.2.8)

0.13

LEPR (Gln/Gln

46 (22.0)

56 (26.8)

1.00

LEPR (Gln/Arg) + (Arg/Arg)

163 (78.0)

153 (73.2)

1.3 (0.8–2.0)

0.26

1.3 (0.8–2.1)

0.23

Pre-menopausal women

(n = 114)

(n = 121)

Allele frequencies

LEPR (Gln)

0.46

0.54

LEPR (Arg)

0.54

0.46

Genotype frequencies

LEPR (Gln/Gln)

23 (20.2)

38 (31.4)

1.00

LEPR (Gln/Arg)

60 (52.6)

54 (44.6)

1.8 (1.0–3.5)

0.06

1.8 (0.9–3.3)

0.07

LEPR (Arg/Arg)

31 (27.2)

29 (24.0)

1.8 (0.9–3.6)

0.12

1.8 (0.8–3.7)

0.14

LEPR (Gln/Gln

23 (20.2)

38 (31.4)

1.00

LEPR (Gln/Arg) + (Arg/Arg)

91 (79.8)

83 (68.6)

1.8 (1.0–3.3)

0.05

1.8 (1.0–3.2)

0.07

Postmenopausal women

(n = 95)

(n = 88)

Allele frequencies

LEPR (Gln)

0.49

0.51

LEPR (Arg)

0.51

0.49

Genotype frequencies

LEPR (Gln/Gln)

23 (24.2)

18 (20.5)

1.00

LEPR (Gln/Arg)

47 (49.5)

53 (60.2)

0.7 (0.3–1.4)

0.33

0.7 (0.4–1.5)

0.42

LEPR (Arg/Arg)

25 (26.3)

17 (19.3)

1.2 (0.5–2.8)

0.75

1.2 (0.5–3.0)

0.62

LEPR (Gln/Gln

23 (24.2)

18 (20.5)

1.00

LEPR (Gln/Arg) + (Arg/Arg)

72 (75.8)

70 (79.5)

0.8 (0.4–1.6)

0.54

0.9 (0.4–1.8)

0.68


*Adjusted for age and waist/hip ratio (WHR)

Okobia et al. BMC Cancer 2008 8:338   doi:10.1186/1471-2407-8-338

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