Survival of nude mice after intracranial injection of recombinant C3 retrovirus into established SHG44 gliomas. SHG44 were implanted into the frontal lobe of nude mice. After 3 days, tumors were injected with a single dose of recombinant C3 retrovirus or PBS (n = 8/group). Compared with animals treated with PBS (dash line), a significant increase in survival occurs in those treated with recombinant C3 retrovirus (solid line) (p < 0.05).
Chen et al. BMC Cancer 2008 8:29 doi:10.1186/1471-2407-8-29