Table 3

Association between ERG and TMPRSS2 SNP genotypes and TMPRSS2-ERG fusion status

Fusion Status


Gene

SNP

Genotype

Negative

Positive

P value


ERG

rs1571704

GG

66 (84.6)

43 (89.6)

GT/TT

12 (15.4)

5 (10.4)

0.59

rs1892570

CC

64 (81.0)

44 (91.7)

CT/TT

15 (19.0)

4 (8.3)

0.13

rs2068967

GG

24 (30.4)

15 (31.3)

GA/AA

55 (69.6)

33 (68.7)

0.10

rs2836370

TT

18 (22.5)

12 (25.5)

TC/CC

62 (77.5)

35 (74.5)

0.83

TMPRSS2

rs12329760

CC

53 (68.0)

26 (53.1)

CT/TT

25 (32.0)

23 (46.9)

0.13

Negative

Translocation

Deletion


ERG

rs1571704

GG

66 (84.6)

18 (85.7)

25 (92.6)

GT/TT

12 (15.4)

3 (14.3)

2 (7.4)

0.66

rs1892570

CC

64 (81.0)

19 (90.5)

25 (92.6)

CT/TT

15 (19.0)

2 (9.5)

2 (7.4)

0.33

rs2068967

GG

24 (30.4)

9 (42.8)

6 (22.2)

GA/AA

55 (69.6)

12 (57.2)

21 (77.8)

0.31

rs2836370

TT

18 (22.5)

5 (23.8)

7 (26.9)

TC/CC

62 (77.5)

16 (76.2)

19 (73.1)

0.91

TMPRSS2

rs12329760

CC

53 (68.0)

8 (38.1)

18 (64.3)

CT/TT

25 (32.0)

13 (61.9)

10 (35.7)

0.05

Negative

Single

Multiple


ERG

rs1571704

GG

66 (84.6)

40 (93.0)

3 (60.0)

GT/TT

12 (15.4)

3 (7.0)

2 (40.0)

0.09

rs1892570

CC

64 (81.0)

40 (93.0)

4 (80.0)

CT/TT

15 (19.0)

3 (7.0)

1 (20.0)

0.15

rs2068967

GG

24 (30.4)

12 (27.9)

3 (60.0)

GA/AA

55 (69.6)

31 (72.1)

2 (40.0)

0.36

rs2836370

TT

18 (22.5)

11 (26.2)

1 (20.0)

TC/CC

62 (77.5)

31 (73.8)

4 (80.0)

0.86

TMPRSS2

rs12329760

CC

53 (68.0)

25 (58.1)

1 (16.7)

CT/TT

25 (32.0)

18 (41.9)

5 (83.3)

0.03


FitzGerald et al. BMC Cancer 2008 8:230   doi:10.1186/1471-2407-8-230

Open Data