Table 1

Comparison of PIK3 CA amplification or p53/p21 protein expression in High Grade Serous Ovarian Tumours

Group

PIK3CA amplification (MIP copy number)

p53/p21 IHC

+/-

+/+, -/-

-/+


BRCA1 loss through mutation

0/9*+

4/9

2/9

3/9

BRCA1 epigenetic loss

7/8*+

8/9**

1/9

0/9

No BRCA1 loss

3/11+

3/12**

5/12

4/12


* p = 0.02 for pairwise comparison based on Bonferroni-Holmes corrected Fisher exact test

** p = 0.03 for pairwise comparison based on Bonferroni-Holmes corrected Fisher exact test

+ p = 0.001 for threeway comparison based on Bonferroni-Holmes corrected Fisher exact test

Press et al. BMC Cancer 2008 8:17   doi:10.1186/1471-2407-8-17

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