Additional file 1.

Immunohistochemical analysis of representative tumours of the KD (animal 9) and SD (animal 16) groups. The carcinoma cells (pan cytokeratin-positive) located within the viable zone around the necrosis have proliferated (Ki-67 antigen-positive) and exhibit a glycolytic phenotype (TKTL1-positive). The expression of Glut-1 correlated with the strong glucose uptake and lactate production shown in Fig. 1 (Magnification: ×250).

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Otto et al. BMC Cancer 2008 8:122   doi:10.1186/1471-2407-8-122