Research article
Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides
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* Corresponding author: Christoph Otto otto_c@chirurgie.uni-wuerzburg.de
- † Equal contributors
1 Experimental Transplantation Immunology, Department of Surgery, University of Würzburg Hospital, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany
2 Department of Obstetrics and Gynaecology, University of Würzburg Hospital, Josef-Schneider-Str. 4, D-97080 Würzburg, Germany
3 Department of Surgery, University of Würzburg Hospital, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany
4 Tavartis GmbH, Kroetengasse 10, D-64853 Otzberg, Germany
5 Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany
BMC Cancer 2008, 8:122 doi:10.1186/1471-2407-8-122
Published: 30 April 2008Additional files
Additional file 1:
Immunohistochemical analysis of representative tumours of the KD (animal 9) and SD (animal 16) groups. The carcinoma cells (pan cytokeratin-positive) located within the viable zone around the necrosis have proliferated (Ki-67 antigen-positive) and exhibit a glycolytic phenotype (TKTL1-positive). The expression of Glut-1 correlated with the strong glucose uptake and lactate production shown in Fig. 1 (Magnification: ×250).
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Additional file 2:
Influence of the ketogenic diet on vascularity in tumours of the human gastric adenocarcinoma cell line 23132/87. Representative tumour sections from the KD (animal 11) and SD (animal 13) groups are shown. Vessels were stained with the rat anti-mouse CD34 antibody RAM34 as described in Methods (Magnification: ×400).
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