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Open Access Highly Accessed Research article

The value of prognostic factors for uterine cervical cancer patients treated with irradiation alone

Rūta Grigienė1*, Konstantinas P Valuckas2, Eduardas Aleknavičius2, Juozas Kurtinaitis3 and Simona R Letautienė1

Author Affiliations

1 Department of Diagnostic Radiology, Oncology Institute of Vilnius University, Santariskiu 1, Vilnius, Lithuania

2 Clinic of Conservative Tumour Therapy, Oncology Institute of Vilnius University, Santariskiu 1, Vilnius, Lithuania

3 Cancer Control and Prevention Center, Oncology Institute of Vilnius University, Santariskiu 1, Vilnius, Lithuania

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BMC Cancer 2007, 7:234  doi:10.1186/1471-2407-7-234

Published: 22 December 2007

Abstract

Background

The aim of our study was to investigate and evaluate the prognostic value of and correlations between preclinical and clinical factors such as the stage of the disease, blood Hb level before treatment, size of cervix and lymph nodes evaluated by CT, age, dose of irradiation and duration of radiotherapy related to overall survival, disease-free survival, local control and metastases-free survival in cervical cancer patients receiving radiotherapy alone.

Methods

162 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIA-IIIB cervical carcinoma treated with irradiation were analysed. Univariate and multivariate analyses using the Cox regression model were performed to determine statistical significance of some tumor-related factors.

Results

The Hb level before treatment showed significant influence on overall survival (p = 0.001), desease free survival (p = 0.040) and local control (p = 0.038). The lymph node status (>10 mm) assessed on CT had impact on overall survival (p = 0,030) and local control (p = 0,036). The dose at point A had impact on disease free survival (p = 0,028) and local control (p = 0,021) and the radiotherapy duration had showed significant influence on overall survival (p = 0,045), disease free survival (p = 0,006) and local control (p = 0,033).

Conclusion

Anemia is a significant and independent prognostic factor of overall survival, disease-free survival and local control in cervical cancer patients treated with irradiation. The size of lymph nodes in CT is an independent prognostic factor for overall survival and local control in cervical cancer patients. The size of cervix uteri evaluated by CT has no prognostic significance in cervical cancer patients treated with radiotherapy. The prognostic value of FIGO stage of cervical cancer is influenced by other factors, analyzed in this study and is not an independent prognostic factor.