Table 2

Rare allele carriage rates in breast cancer and controls

Groups

Rare allele (A) carriage rate (%)

Odds Ratio (95% CI)

Test statistic (p value)#


Cancer

Controls


Overall

136/846 (16.1%)

115/707 (16.3%)

0.99 (0.75–1.29)

×2 = 0.001; p = 0.97

Positive family history*

38/231 (16.5%)

22/153 (14.4%)

0.17 (0.66–2.07)

×2 = 0.16; p = 0.69

Negative family history*

98/615 (15.9%)

93/554 (16.8%)

0.94 (0.69–1.28)

×2 = 0.1; p = 0.75

Young patients** vs. controls

20/130 (15.4%)

115/707 (16.3%)

0.94 (0.56–1.57)

×2 = 0.01; p = 0.90


# Pearson's chi-square test (with Yates correction where applicable)

*Family history: either first or second-degree relative with breast cancer

**Young cancer patients: </= 50 years of age

Balasubramanian et al. BMC Cancer 2007 7:107   doi:10.1186/1471-2407-7-107

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