Table 2 |
|||||||
|
TP53 mutations in breast tumors |
|||||||
|
Tumor Sample |
CGH Subtype |
TP53 Mutation |
Copy Number |
Loss of Function1 |
Gain of Function1 |
Dom. Neg.1 |
TS1 |
|
|
|||||||
|
S0013 |
Complex |
Y205D |
Loss |
NA |
NA |
NA |
NA |
|
S0184 |
Complex |
R175H |
Loss |
Yes |
Yes |
Yes |
No |
|
S0269 |
Complex |
M237I |
Loss |
NA |
NA |
No |
NA |
|
S1511 |
Complex |
C275Y |
Loss |
NA |
NA |
No |
NA |
|
S0001 |
Mixed amplifier |
Y234C |
No Loss |
Yes |
NA |
NA |
Yes |
|
S0043 |
Mixed amplifier |
Y163C |
No Loss |
Yes |
Yes |
No |
NA |
|
S0055 |
Mixed amplifier |
196 Stop |
Loss |
NA |
NA |
No |
NA |
|
S0126 |
Mixed amplifier |
intron 5/6 |
Loss |
NA |
NA |
NA |
NA |
|
S1503 |
Mixed amplifier |
C176Y |
Loss |
Yes |
NA |
Yes |
NA |
|
S1579 |
Mixed amplifier |
G245C |
Loss |
Yes |
NA |
Yes |
NA |
|
|
|||||||
|
1From IARC TP53 database release, R10, July 2005 [48]. Function assayed in either human or yeast. Dom. Neg., Dominant Negative. TS, Temperature sensitive. |
|||||||
|
Fridlyand et al. BMC Cancer 2006 6:96 doi:10.1186/1471-2407-6-96 |
|||||||
