Open Access Highly Accessed Research article

Breast tumor copy number aberration phenotypes and genomic instability

Jane Fridlyand12, Antoine M Snijders23, Bauke Ylstra34, Hua Li23, Adam Olshen25, Richard Segraves6, Shanaz Dairkee27, Taku Tokuyasu23, Britt Marie Ljung28, Ajay N Jain23, Jane McLennan2, John Ziegler2, Koei Chin26, Sandy Devries26, Heidi Feiler29, Joe W Gray29, Frederic Waldman26, Daniel Pinkel26 and Donna G Albertson236*

Author Affiliations

1 Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, San Francisco, CA 94143, USA

2 University of California San Francisco Comprehensive Cancer Center, San Francisco, CA 94143, USA

3 Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143-0808, USA

4 Micro Array Core Facility, VUMC University Medical Center, 1081BT Amsterdam, The Netherlands

5 Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York 20021, USA

6 Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143-0808, USA

7 Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA

8 Department of Pathology, University of California San Francisco, San Francisco, California, USA

9 Division of Life Sciences, Lawrence Berkeley National Laboratory, Berkeley, CA, USA

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BMC Cancer 2006, 6:96  doi:10.1186/1471-2407-6-96

Published: 18 April 2006

Additional files

Additional File 1:

Additional file 1 – Supplementary Table 1. Patient CharacteristicsProvides information on patient samples.

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Additional File 2:

Additional file 2 – Supplementary Statistical Methods Provides a detailed description of statistical methods.

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Additional File 3:

Additional file 3 – Supplementary Table 2. Array CGH data Provides array CGH log2ratios for clones and genome order for all samples.

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Additional File 4:

Additional file 4 – Supplementary Table 3. Genome stability genes and associations with copy number aberrations Provides information on 426 genome stability genes and associations with copy number aberration types.

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Additional File 5:

Additional file 5 – Supplementary Table 4. Genome stability genes and their relation to E2F. Table provides information on whether the genes are known targets of E2F1, correlation of their expression with E2F1, correlation of their expression with copy number in samples in which copy number of the locus is reduced.

Format: XLS Size: 395KB Download file

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