Table 2

APC mutational spectra detected in all adenoma/CRC cases, and cases divided according to smoking status.
Type of mutationa
 All cases n = 133 Total number of mutations
 Ever smokers*b n = 88
 Never smokers*b n = 39




Silent/missense mutation
 Truncation mutation
 Silent/missense mutation
 Truncation mutation
Transitions
 31(39%)
 13 (72%)
 7 (25%)
 7 (50%)
 2 (13%)
C → T
 17
 2
 7
 4
 2
G → A
 9
 6
 -
 3
 -
A → G
 4
 4
 -
 -
 -
T → C
 1
 1
 -
 -
 -
Transversion
 21(26%)
 5 (28%)
 5 (18%)
 7 (50%)
 2 (13%)
A → C
 -
 -
 -
 -
 -
T → G
 2
 1
 -
 1
 -
A → T
 1
 -
 1
 -
 -
T → A
 4
 2
 -
 2
 -
C → A
 3
 1
 2
 -
 -
G → T
 6
 1
 2
 1
 2
C → G
 -
 -
 -
-
G → C
 3
 -
 -
 3
 -
Frameshift
 28 (35%)
 -
 16 (57%)
 -
 11 (74%)
Total
 80
 18
 28
 14
 15

*Missing values for ever and never smoking gave rise to diminished numbers of cases and mutations.

a The frequency is calculated by dividing the number of transitions, transversions and framshift mutations separately to the total number of either silent/missens or truncated mutations for ever and never smokers.

bThere is no significant difference between ever smokers and never smokers in relation to the mutational spectra (transitions, transversions and frameshift) for missens/silent or truncated mutations P = 0.094 and 0.558, respectively.

Sæbø et al. BMC Cancer 2006 6:71   doi:10.1186/1471-2407-6-71