Figure 1.

Modular organization of the main t(9;22) translocation products. The protein sizes are not to scale. CC – coiled coil oligomerization interface; S/T kinase – serine/threonine kinase domain; DH – dbl homology domain; PH – pleckstrin homology domain; GAP – GTPase activation domain; STEV – PDZ-binding motif; SH3, SH2 – Src-homology domain 3 and 2; Y-kinase – tyrosine kinase domain (SH1), AB – actin-binding domain; der 9 and der 22 – derivative 9 and 22.