Open Access Research article

Four cycles of paclitaxel and carboplatin as adjuvant treatment in early-stage ovarian cancer: a six-year experience of the Hellenic Cooperative Oncology Group

Aristotle Bamias1*, Christos Papadimitriou1, Eleni Efstathiou1, Alexandros Rodolakis2, Georgios Vlahos2, Zannis Voulgaris2, Georgios Bozas1, Georgios Fountzilas3, Gerassimos Aravantinos4, Evagelia Razis5, Dimitra Gika1 and Meletios A Dimopoulos1

Author Affiliations

1 Department of Clinical Therapeutics, Medical School, University of Athens, Athens, Greece

2 First Department of Obstetrics and Gynaecology, Medical School, University of Athens, Athens, Greece

3 Aristotle University of Thessaloniki, School of Medicine, Thessaloniki, Greece

4 Third Medical Department, Agii Anargyri Hospital, Athens, Greece

5 Hygia Hospital, Athens, Greece

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BMC Cancer 2006, 6:228  doi:10.1186/1471-2407-6-228

Published: 25 September 2006

Abstract

Background

Surgery can cure a significant percentage of ovarian carcinoma confined to the pelvis. Nevertheless, there is still a 10–50% recurrence rate. We administered paclitaxel/carboplatin as adjuvant treatment in early-stage ovarian carcinoma.

Methods

Patients with stages Ia or Ib, Grade 2 or 3 and Ic to IIb (any grade) were included. Patients were treated with 4 cycles of Paclitaxel 175 mg/m2 and Carboplatin [area under the curve (AUC) 6 (Calvert Formula)] every 3 weeks.

Results

Sixty-nine patients with no residual disease following cytoreductive surgery and minimal or modified surgical staging were included in this analysis. Grade 3 or 4 neutropenia occured in 29.9% of patients, while neutropenic fever was reported in 4.5%. Neurotoxicity (all Grade 1 or 2) was reported in 50% of cases. Median follow-up was 62 months. 5-year overall survival (OS) and relapse-free survival (RFS) were: 87% (95% confidence intervals [CI]: 78–96) and 79% (95% CI: 69–89), respectively. Significantly fewer patients with stages Ic-IIb and tumor grade 2 or 3 achieved a 5-year RFS than patients with only one of these two factors (73% vs 92%, p = 0.03).

Conclusion

Paclitaxel/Carboplatin chemotherapy is a safe and effective adjuvant treatment in early-stage ovarian carcinoma. Patients with stages Ic-IIb and tumor grade 2 or 3 may benefit from more extensive treatment.