Table 6

Genotype frequencies of the seven polymorphisms in subgroups of invasive breast cancer.

Tumour Severity

Subgroups

Genotype frequencies (%)

Chi square test for trend (P value)


1:1

1:2

2:2


IL1A +4845 G>T


Tumour Grade

Grade 1 (n = 122)

62 (50.8%)

50 (41%)

10 (8.2%)

X2 = 0.037; p = 0.85

Grade 2 (n = 283)

151 (53.4%)

109 (38.5%)

23 (8.1%)

Grade 3 (n = 216)

115 (53.2%)

82 (38%)

19 (8.8%)

Nodal Involvement

Absent (n = 430)

204 (47.4%)

118 (43.7%)

38 (8.8%)

X2 = 4.75; p = 0.03*

Present (n = 117)

117 (59.4%)

63 (32%)

17 (8.6%)

Vascular Invasion

Absent (n = 467)

243 (52%)

185 (39.6%)

39 (8.4%)

X2 = 0.058; p = 0.81

Present (n = 117)

64 (54.7%)

42 (35.9%)

11 (9.4%)


IL1B -511 C>T


Tumour Grade

Grade 1 (n = 126)

51 (40.5%)

59 (46.8%)

16 (12.7%)

X2 = 0.12; p = 0.73

Grade 2 (n = 284)

150 (52.8%)

111 (39.1%)

23 (8.1%)

Grade 3 (n = 216)

98 (45.4%)

93 (43.1%)

25 (11.6%)

Nodal Involvement

Absent (n = 434)

214 (49.3%)

179 (41.2%)

41 (9.4%)

X2 = 0.79; p = 0.37

Present (n = 198)

90 (45.5%)

87 (43.9%)

21 (10.6%)

Vascular Invasion

Absent (n = 473)

224 (47.4%)

201 (42.5%)

48 (10.1%)

X2 = 0.38; p = 0.54

Present (n = 116)

57 (49.1%)

50 (43.1%)

9 (7.8%)


IL1B +3954 C>T


Tumour Grade

Grade 1 (n = 121)

68 (56.2%)

48 (39.7%)

5 (4.1%)

X2 = 0.053; p = 0.82

Grade 2 (n = 279)

173 (62%)

90 (32.3%)

16 (5.7%)

Grade 3 (n = 215)

131 (60.9%)

70 (32.6%)

14 (6.5%)

Nodal Involvement

Absent (n = 427)

244 (57.1%)

161 (37.7%)

22 (5.2%)

X2 = 0.37; p = 0.54

Present (n = 194)

120 (61.9%)

61 (31.4%)

13 (6.7%)

Vascular Invasion

Absent (n = 464)

283 (61%)

157 (33.8%)

24 (5.2%)

X2 = 0.43; p = 0.51

Present (n = 114)

66 (57.9%)

41 (36%)

7 (6.1%)


IL1RN +2018 T>C


Tumour Grade

Grade 1 (n = 125)

55 (44%)

55 (44%)

15 (12%)

X2 = 0.73; p = 0.40

Grade 2 (n = 280)

150 (53.6%)

107 (38.2%)

23 (8.2%)

Grade 3 (n = 215)

108 (50.2%)

86 (40%)

21 (9.8%)

Nodal Involvement

Absent (n = 429)

216 (50.3%)

180 (42%)

33 (7.7%)

X2 = 0.11; p = 0.74

Present (n = 196)

102 (52%)

72 (36.7%)

22 (11.2%)

Vascular Invasion

Absent (n = 463)

232 (50.1%)

191 (41.3%)

40 (8.6%)

X2 = 1.34; p = 0.25

Present (n = 118)

67 (56.8%)

42 (35.6%)

9 (7.6%)


IL4R +1902 A>G


Tumour Grade

Grade 1 (n = 137)

87 (63.5%)

44 (32.1%)

6 (4.4%)

X2 = 0.14; p = 0.71

Grade 2 (n = 308)

195 (63.3%)

97 (31.5%)

16 (5.2%)

Grade 3 (n = 228)

146 (64%)

75 (32.9%)

7 (3.1%)

Nodal Involvement

Absent (n = 477)

313 (65.6%)

144 (30.2%)

20 (4.2%)

X2 = 0.11; p = 0.75

Present (n = 212)

135 (63.7%)

69 (32.5%)

8 (3.8%)

Vascular Invasion

Absent (n = 508)

316 (62.2%)

170 (33.5%)

22 (4.3%)

X2 = 0.002; p = 0.96

Present (n = 129)

82 (63.6%)

40 (31%)

7 (5.4%)


IL6 -174 G>C


Tumour Grade

Grade 1 (n = 80)

26 (32.5%)

38 (47.5%)

16 (20%)

X2 = 0.04; p = 0.84

Grade 2 (n = 204)

78 (38.2%)

95 (46.6%)

31 (15.2%)

Grade 3 (n = 159)

49 (30.8%)

83 (52.2%)

27 (17%)

Nodal Involvement

Absent (n = 293)

100 (34.1%)

141 (48.1%)

52 (17.7%)

X2 = 0.20; p = 0.66

Present (n = 143)

52 (36.4%)

67 (46.9%)

24 (16.8%)

Vascular Invasion

Absent (n = 325)

112 (34.5%)

159 (48.9%)

54 (16.6%)

X2 = 0.001; p = 0.98

Present (n = 85)

29 (34.1%)

42 (49.4%)

14 (16.5%)


IL10 -1082 G>A


Tumour Grade

Grade 1 (n = 80)

23 (28.8%)

37 (46.3%)

20 (25%)

X2 = 0.37; p = 0.54

Grade 2 (n = 205)

39 (19%)

113 (55.1%)

53 (25.9%)

Grade 3 (n = 158)

44 (27.8%)

79 (50%)

35 (22.2%)

Nodal Involvement

Absent (n = 293)

69 (23.5%)

148 (50.5%)

76 (25.9%)

X2 = 0.84; p = 0.36

Present (n = 143)

38 (26.6%)

73 (51%)

32 (22.4%)

Vascular Invasion

Absent (n = 325)

87 (26.8%)

156 (48%)

82 (25.2%)

X2 = 3.3; p = 0.07

Present (n = 85)

12 (14.1%)

49 (57.6%)

24 (28.2%)


Balasubramanian et al. BMC Cancer 2006 6:188   doi:10.1186/1471-2407-6-188

Open Data