Table 3

One-way sensitivity analysis.

Variables

Base- Case Values

Sensitivity Analysis Values

Incremental Cost($)/Life-Year Saved


DNA3

DNA5

DNA10


Range

Threshold

Range

Threshold

Range

Threshold


Base-case

9,794

9,335

7,717

Sensitivity of DNA for small/large adenoma

8%/15%

75%/82%

11,546 – 1,742

--

11,122 – 1,030

--

9,369 – 269

--

Sensitivity of DNA for preclinical CRC

52%

50%–100%

9,921 – 7,078

--

9,454 – 6,752

--

7,817 – 5,528

--

Cost per DNA

$44.1

$22.1-$88.1

4,344 – 2,0706

$57.1

4,194 – 19,628

$60.0

3,271 – 1,6618

$70.3

Compliance with DNA

60%

10%–100%

9,070 – 10,423

--

9,047 – 9,582

--

7,630 – 7,787

--

Referral rate to diagnostic colonoscopy

85%

10%–100%

85,266 – 8,294

67%

83,868 – 7,843

63%

73,826 – 6,396

53%

Prevalence of large adenoma

3.82%

0.96%–7.64%

18,969 – 5,387

2.42%

18,184 – 5,114

2.23%

15,657 – 4,042

1.58%

Discount rate

3%

0%–7%

6,938 – 15,674

--

6,738 – 14,864

--

5,107 – 13,281

--


DNA3, stool DNA testing every 3 years; DNA5, stool DNA testing every 5 years; DNA10, stool DNA testing every 10 years; FOBT1, fecal occult blood testing every two year; SIGM5, sigmoidoscopy every 5 years; COLO10, colonoscopy every 10 years.

Wu et al. BMC Cancer 2006 6:136   doi:10.1186/1471-2407-6-136

Open Data