Table 3 |
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|
One-way sensitivity analysis. |
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|
Variables |
Base- Case Values |
Sensitivity Analysis Values |
Incremental Cost($)/Life-Year Saved |
|||||
|
|
||||||||
|
DNA3 |
DNA5 |
DNA10 |
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|
|
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|
Range |
Threshold |
Range |
Threshold |
Range |
Threshold |
|||
|
|
||||||||
|
Base-case |
9,794 |
9,335 |
7,717 |
|||||
|
Sensitivity of DNA for small/large adenoma |
8%/15% |
75%/82% |
11,546 – 1,742 |
-- |
11,122 – 1,030 |
-- |
9,369 – 269 |
-- |
|
Sensitivity of DNA for preclinical CRC |
52% |
50%–100% |
9,921 – 7,078 |
-- |
9,454 – 6,752 |
-- |
7,817 – 5,528 |
-- |
|
Cost per DNA |
$44.1 |
$22.1-$88.1 |
4,344 – 2,0706 |
$57.1 |
4,194 – 19,628 |
$60.0 |
3,271 – 1,6618 |
$70.3 |
|
Compliance with DNA |
60% |
10%–100% |
9,070 – 10,423 |
-- |
9,047 – 9,582 |
-- |
7,630 – 7,787 |
-- |
|
Referral rate to diagnostic colonoscopy |
85% |
10%–100% |
85,266 – 8,294 |
67% |
83,868 – 7,843 |
63% |
73,826 – 6,396 |
53% |
|
Prevalence of large adenoma |
3.82% |
0.96%–7.64% |
18,969 – 5,387 |
2.42% |
18,184 – 5,114 |
2.23% |
15,657 – 4,042 |
1.58% |
|
Discount rate |
3% |
0%–7% |
6,938 – 15,674 |
-- |
6,738 – 14,864 |
-- |
5,107 – 13,281 |
-- |
|
|
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|
DNA3, stool DNA testing every 3 years; DNA5, stool DNA testing every 5 years; DNA10, stool DNA testing every 10 years; FOBT1, fecal occult blood testing every two year; SIGM5, sigmoidoscopy every 5 years; COLO10, colonoscopy every 10 years. |
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|
Wu et al. BMC Cancer 2006 6:136 doi:10.1186/1471-2407-6-136 |
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