Table 1

Percentage of reported EGFR-amplification/overexpression in patients with glioblastoma multiforme: Literature overview. Abbreviations: Southern Blot (SB), Immunohistochemistry (IHC), Western Blot (WB), Polymerase Chain Reaction (PCR), In situ hybridization (ISH), Fluorescence In-Situ Hybridization (FISH).
Author (Reference)
 Year of publication
 Patients (n)
 Patients with EGFR-amplification (n)
 Patients with EGFR-overexpression (n)
 Method of EGFR evaluation
Quan et al.
 2005
 107
 36 (32%)
 -
 ISH
Mellinghoff et al.
 2005
 25
 12 (48%)
 -
 FISH, PCR
Shinojima et al.
 2003
 87
 40 (46%)
 -
 SB, IHC
Schmidt et al.
 2002
 91
 26 (29%)
 -
 PCR
Barker et al.
 2001
 162
 -
 53 (33%)
 IHC
Simmons et al.
 2001
 110
 -
 39 (35%)
 IHC
Chakravarti et al.
 2001
 56
 -
 23 (41%)
 WB
Smith et al.
 2001
 111
 46 (41%)
 -
 FISH, PCR
Yoon et al.
 2001
 36
 13 (36%)
 12 (33%)
 PCR, IHC
Korshunov et al.
 1999
 168
 -
 102 (61%)
 IHC
Olson et al.
 1998
 70
 19 (27%)
 -
 SB
Bouvier-Labit et al.
 1998
 63
 -
 22 (35%)
 IHC
Newcomb et al.
 1998
 80
 -
 28 (35%)
 IHC
Korkopopoulou et al.
 1997
 37
 -
 17 (64%)
 IHC
Rainov et al.
 1997
 71
 -
 54 (76%)
 IHC
Liu et al.
 1997
 63
 31 (49%)
 -
 SB
Waha et al.
 1996
 54/62
 18 (33%)
 32 (52%)
 PCR, IHC
Zhu et al.
 1996
 55
 -
 39 (71%)
 IHC
Diedrich et al.
 1995
 32/22
 13 (41%)
 19 (86%)
 ISH
Kordek et al.
 1995
 30
 -
 10 (33%)
 IHC
Schober et al.
 1995
 21
 13 (62%)
 -
 PCR, IHC
Schlegel et al.
 1994
 42
 19 (45%)
 27 (64%)
 SB, PCR, WB
Hiesinger et al.
 1993
 17
 -
 4 (24%)
 IHC
Hurtt et al.
 1992
 19
 6 (32%)
 -
 Dot blot
Jaros et al.
 1992
 20
 -
 19 (95%)
 IHC
Torp et al.
 1992
 20
 8 (40%)
 -
 SB
Bigner et al.
 1988
 48
 20 (42%)
 NR
 SB, slot blot
Wong et al.
 1987
 47
 20 (43%)
 -
 SB, slot blot

Combs et al. BMC Cancer 2006 6:133   doi:10.1186/1471-2407-6-133